一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Environmental Science and Pollution Research >>article
Environmental Science and Pollution Research

Environmental Science and Pollution Research

IF: 5.8
Download PDF

Curcumin strengthens a spontaneous self-protective mechanism-SP1/PRDX6 pathway, against di-n-butyl phthalate-induced testicular ferroptosis damage

Published:1 December 2023 DOI: 10.1007/s11356-023-30962-2 PMID: 37966654
Hengtao Bu,?Bao Wang,?Yulin Wu,?Pu Li,?Yankang Cui,?Xuping Jiang,?Xiaowen Yu,?Bianjiang Liu,?Min Tang

Abstract

As one of the common plasticizers, di-n-butyl phthalate (DBP) has been using in various daily consumer products worldwide. Since it is easily released from products and exists in the environment for a long time, it has a lasting impact on human health, especially male reproductive health. However, the detailed mechanism of testicular damage from DBP and the protection strategy are still not clear enough. In this study, we found that DBP could induce dose-dependent ferroptosis in testicular tissue. Mechanism dissection indicates that DBP can upregulate SP1 expression, which could directly transcriptionally upregulate PRDX6, a negative regulator of ferroptosis. Overexpression of PRDX6 or adding SP1 agonist curcumin could suppress the DBP-induced ferroptosis on testicular cells. In vivo, rats were given 500 mg/kg/day DBP orally for 3 weeks; elevated levels of ferroptosis were detected in testicular tissue. When the above-mentioned doses of DBP and curcumin at a dose of 300 mg/kg/day were administered intragastrically simultaneously, the testicular ferroptosis induced by DBP was alleviated. Immunohistochemistry and quantitative real-time PCR of testis tissue showed that the expression of PRDX6 was upregulated under the action of DBP and curcumin. These findings suggest a spontaneous self-protection mechanism of testicular tissue from DBP damage by upregulating SP1 and PRDX6. However, it is not strong enough to resist the DBP-induced ferroptosis. Curcumin can strengthen this self-protection mechanism and weaken the level of ferroptosis induced by DBP.?This study may help us to develop a novel therapeutic option with curcumin to protect the testicular tissue from ferroptosis and function impairment by DBP.

Substances (6)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Curcumin 458-37-7 C21H20O6 1294 suppliers $5.00-$1280.00
Curcumin 458-37-7 C21H20O6 1294 suppliers $5.00-$1280.00
Curcumin 458-37-7 C21H20O6 1294 suppliers $5.00-$1280.00
Curcumin 458-37-7 C21H20O6 1294 suppliers $5.00-$1280.00
Curcumin 458-37-7 C21H20O6 - Inquiry
Curcumin 458-37-7 C21H20O6 - Inquiry

Similar articles

IF:0.9

Assessment of the protective action of diphosphonate compounds against damage to T-lymphocytes by antilymphocytic serum

Bulletin of Experimental Biology and Medicine I. Zernov,?D. Stefani,etc Published: 1 March 1979
IF:5.4

Protective effects and mechanism of puerarin targeting PI3K/Akt signal pathway on neurological diseases.

ACS Applied Energy Materials Qian Wang, Zi-Nuo Shen,etc Published: 24 October 2022
IF:10.1

Integrating biomonitoring exposure data into the risk assessment process: phthalates [diethyl phthalate and di(2-ethylhexyl) phthalate] as a case study.

Environmental Health Perspectives Antonia M Calafat,?Richard H McKee,etc Published: 1 November 2006
庄河市| 那曲县| 惠来县| 宣威市| 西充县| 湟中县| 通化市| 贵阳市| 潮州市| 河曲县| 文水县| 湟中县| 怀远县| 新宾| 右玉县| 吉首市| 昭觉县| 崇阳县| 七台河市| 武安市| 遵义市| 资中县| 云和县| 拉萨市| 芜湖市| 东宁县| 金湖县| 兰溪市| 淳化县| 克拉玛依市| 绥江县| 喀喇沁旗| 板桥市| 开鲁县| 呈贡县| 拉孜县| 雷州市| 高陵县| 厦门市| 安龙县| 丰镇市|