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World neurosurgery

World neurosurgery

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Expression of Histone H1 in Rats with Traumatic Brain Injury and the Effect of the NLRP3 Inflammasome Pathway

Published:1 March 2023 DOI: 10.1016/j.wneu.2022.12.009 PMID: 36509326
Qiangbin Zhu , Feng Zheng , Wei You MD , Xiaodong Kang , Chunhui Chen , Zhigang Pan , Jianfeng Zhou MD , Weipeng Hu

Abstract

Objective

To explore expression of histone H1 after traumatic brain injury (TBI) and the effect of the nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3) inflammasome pathway on its expression.

Methods

Of 24 rats, 15 were randomly divided into a sham and 4 TBI groups, with 3 rats in each group; the remaining 9 rats were randomly divided into sham group, TBI group, and TBI+CY-09 group, with 3 rats in each group. The expression of histone H1 in rat serum was detected by enzyme-linked immunosorbent assay; Western blot was used to detect the expression of target protein in the injured brain tissue of rats.

Results

On the 3rd day after TBI, compared with the sham group, the expression of histone H1 was decreased (P < 0.05). After inhibiting the NLRP3 inflammasome pathway with CY-09, expressions of IL-1β, IL-18, and histone H1 in rat-injured brain tissue in the TBI+CY-09 group were decreased compared with the TBI group (P < 0.05).

Conclusions

The expression of histone H1 decreased significantly from the 3rd day after TBI. Inhibiting the NLRP3 inflammasome pathway may reduce the expression of histone H1. The expression of histone H1 was affected by the microglia-related central nervous system inflammatory response.

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CY-09 1073612-91-5 C19H12F3NO3S2 89 suppliers Inquiry
CY-09 1073612-91-5 C19H12F3NO3S2 89 suppliers Inquiry
CY-09 1073612-91-5 C19H12F3NO3S2 89 suppliers Inquiry
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