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ChemicalBook >> journal list >> International Scientific Journal of Engineering and Management >>article

FORMULATION AND EVALUATION OF OINTMENT CONTAINING CRISABOROLE

Published:24 August 2023 DOI: 10.55041/isjem01301
Shubham Vijay Patel

Abstract

Crisaborole has broad-spectrum anti-inflammatory activity by mainly targeting phosphodiesterase 4 (PDE4) enzyme that is a key regulator of inflammatory cytokine production. As this enzyme is expressed in keratinocytes and immune cells, crisaborole mediates an anti-inflammatory effect on almost all inflammatory cells. Topical application of this drug is useful as it potentiates the localization of this drug in the skin and this anti-inflammatory activity is in the low micromolar range. The objective of present research work is to enhance the aqueous solubility of poorly water soluble drug Crisaborole using Co-solvency technique. The prepared formulation was evaluated for physical characteristics, drug content and drug release. Keywords: Crisaborole, Ointment, Co-solvency

Substances (1)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Crisaborole 906673-24-3 C14H10BNO3 486 suppliers $8.00-$3590.00

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