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iScience

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Roseburia intestinalis relieves intrahepatic cholestasis of pregnancy through bile acid/FXR-FGF15 in rats.

Published:3 November 2023 DOI: 10.1016/j.isci.2023.108392
Hanxiang Sun , Xiujuan Su , Yang Liu , Guohua Li , Qiaoling Du

Abstract

Previous research has demonstrated significant differences in intestinal flora between pregnant women with intrahepatic cholestasis of pregnancy (ICP) and healthy pregnant women. The objective of our study is to identify the key bacteria involved in ICP rats and explore the underlying mechanism. We established an ICP rat model and collected rat feces for metagenomic sequencing and found that Roseburia intestinalis (R.I) is the key bacteria in ICP. Transplantation of R.I improved phenotypes associated with ICP through the bile acid/farnesoid X receptor-fibroblast growth factor 15 (FXR-FGF15) signaling pathway. We used the FXR antagonist Z-Guggulsterone (Z-Gu) to verify the key role of FXR in ICP and found that Z-Gu reversed the benefits of R.I on ICP rats. Our research highlights the important role of intestinal flora in the pathogenesis of ICP and provides a novel approach for its treatment.

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Materials Related products
Procduct Name CAS Molecular Formula Supplier Price
Ethinyl Estradiol 57-63-6 C20H24O2 590 suppliers $6.00-$4262.00
Ethinyl Estradiol 57-63-6 C20H24O2 590 suppliers $6.00-$4262.00
(Z)-Guggulsterone 39025-23-5 C21H28O2 162 suppliers $44.00-$4900.00
(Z)-Guggulsterone 39025-23-5 C21H28O2 162 suppliers $44.00-$4900.00

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