一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Journal of Antibiotics >>article
Journal of Antibiotics

Journal of Antibiotics

IF: 2.1
Download PDF

Evaluation of A-ring hydroxymethylene-amino- triterpenoids as inhibitors of SARS-CoV-2 spike pseudovirus and influenza H1N1

Published:24 November 2023 DOI: 10.1038/s41429-023-00677-0 PMID: 38001284
Oxana Kazakova, Xinyuan Ma, Elena Tretyakova, Irina Smirnova, Alexander Slita, Ekaterina Sinegubova, Vladimir Zarubaev, Hongwei Jin, Demin Zhou, Sulong Xiao

Abstract

A set of triterpene A-ring hydroxymethylene-amino-derivatives was synthesized and their antiviral activity was studied. The synthesized compounds were tested for their potential inhibition of SARS-CoV-2 pseudovirus in BHK-21-hACE2 cells and influenza A/PuertoRico/8/34 (H1N1) virus in MDCK cell culture. Compounds 6, 8 and 19 showed significant anti-SARS-CoV-2 pseudovirus activity with EC50 value of 3.20-11.13?μM, which is comparable to the positive control amodiaquine (EC50 3.17?μM). Among them, 28-O-imidazolyl-azepano-betulin 6 and C3-hydroxymethylene-amino-glycyrrhetol-11,13-diene 19 were identified as the lead compounds with SI values of 7 and 10. The binding mode of compound 6 into the RBD domain of SARS-CoV-2 spike glycoprotein (PDB code: 7DK3) by docking and molecular dynamics simulation was investigated.

Similar articles

额尔古纳市| 响水县| 龙川县| 栖霞市| 广灵县| 鄂伦春自治旗| 连城县| 兴和县| 盈江县| 肥乡县| 庆城县| 商城县| 襄垣县| 德庆县| 育儿| 泾阳县| 长乐市| 恭城| 奉化市| 吉木萨尔县| 东乌珠穆沁旗| 金阳县| 行唐县| 南京市| 高安市| 鄢陵县| 宜春市| 菏泽市| 清流县| 乌审旗| 山阴县| 资阳市| 广汉市| 绍兴市| 吴旗县| 盐源县| 密山市| 盈江县| 扎鲁特旗| 高台县| 滁州市|