一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> PLoS ONE >>article
PLoS ONE

PLoS ONE

IF: 2.9
Download PDF

Does amiodarone impact on apixaban levels? The effect of amiodarone on apixaban level among Thai patients with non-valvular Atrial Fibrillation.

Published:19 January 2024 DOI: 10.1371/journal.pone.0295511 PMID: 38241292
Sutee Limcharoen,?Sarawuth Limprasert,?Pornwalai Boonmuang,?Manat Pongchaidecha,?Juthathip Suphanklang,?Weerayuth Saelim,?Wichai Santimaleeworagun,?Piyarat Pimsi

Abstract

Background: Apixaban and amiodarone are drugs used for non-valvular atrial fibrillation (NVAF) in routine practice. The evidence about apixaban plasma levels in patients who receive apixaban with amiodarone, including bleeding outcomes, has been limited. This study aimed to compare the apixaban plasma levels and bleeding outcomes between apixaban monotherapy and apixaban with amiodarone groups.

Methods: This study was a prospective, observational, and single-center research which was conducted from January 2021 to January 2022 in NVAF patients who received apixaban at a tertiary care hospital located in the center of Bangkok, Thailand.

Results: Thirty-three patients were measured for their median (5th-95th percentile) apixaban plasma levels. The trough of apixaban plasma level (Ctrough) were 108.49 [78.10-171.52] and 162.05 [87.94-292.88] μg/L in the apixaban monotherapy and apixaban with amiodarone groups, respectively (p = 0.028). Additionally, the peaks of apixaban plasma level (Cpeak) were 175.36 [122.94-332.34] and 191 [116.88-488.21] μg/L in the apixaban monotherapy and apixaban with amiodarone groups, respectively (p = 0.375). There was bleeding that occurred in 7 patients (21.21%); 5 patients in the apixaban monotherapy group and 2 patients in the apixaban with amiodarone group, respectively.

Conclusions: Amiodarone may increase the peaks and troughs of apixaban plasma levels. The co-administration of apixaban with amiodarone is generally well tolerated. However, the careful observation of bleeding symptoms in individual cases is necessary to ensure safety.

Substances (2)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Apixaban 503612-47-3 C25H25N5O4 894 suppliers $5.00-$3036.00
Amiodarone 1951-25-3 C25H29I2NO3 156 suppliers Inquiry

Similar articles

IF:9.6

Interventions for Preventing Thromboembolic Events in Patients With Atrial Fibrillation: A Systematic Review.

ACS Materials Letters Angela Lowenstern, Sana M Al-Khatib,etc Published: 4 December 2018
IF:4.3

The effect of pH and triethanolamine on sulfisoxazole complexation with hydroxypropyl-β-cyclodextrin

European Journal of Pharmaceutical Sciences Granero Gladys, Garnero Claudia,etc Published: 1 November 2003
阳新县| 长寿区| 湛江市| 芷江| 琼中| 盐边县| 金华市| 东兴市| 扬中市| 富顺县| 三原县| 呼玛县| 高密市| 岑溪市| 托克逊县| 吴旗县| 集安市| 安远县| 衡南县| 德格县| 昭通市| 静宁县| 大竹县| 三台县| 清流县| 巴林左旗| 荔浦县| 罗山县| 赣州市| 河西区| 南木林县| 双柏县| 固阳县| 巩留县| 隆安县| 甘南县| 思南县| 万荣县| 万山特区| 抚远县| 武鸣县|