一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Molecular Carcinogenesis >>article
Molecular Carcinogenesis

Molecular Carcinogenesis

IF: 3
Download PDF

SN-38, an active metabolite of irinotecan, inhibits transcription of nuclear factor erythroid 2-related factor 2 and enhances drug sensitivity of colorectal cancer cells

Published:1 April 2024 DOI: 10.1002/mc.23685 PMID: 38270247
Jingya Wang,?Jiangli Xu,?Shuhui Yang,?Liu He,?Wenhuai Xu,?Yan'e Liu,?Baoshan Cao,?Siwang Yu

Abstract

Nuclear factor erythroid 2-related factor 2 (Nrf2) significantly contributes to drug resistance of cancer cells, and Nrf2 inhibitors have been vigorously pursued. Repurposing of existing drugs, especially anticancer drugs, is a straightforward and promising strategy to find clinically available Nrf2 inhibitors and effective drug combinations. Topoisomerase inhibitors SN-38 (an active metabolite of irinotecan), topotecan, mitoxantrone, and epirubicin were found to significantly suppress Nrf2 transcriptional activity in cancer cells. SN-38, the most potent one among them, significantly inhibited the transcription of Nrf2, as indicated by decreased mRNA level and binding of RNA polymerase II to NFE2L2 gene, while no impact on Nrf2 protein or mRNA degradation was observed. SN-38 synergized with Nrf2-sensitive anticancer drugs such as mitomycin C in killing colorectal cancer cells, and irinotecan and mitomycin C synergistically inhibited the growth of SW480 xenografts in nude mice. Our study identified SN-38 and three other topoisomerase inhibitors as Nrf2 inhibitors, revealed the Nrf2-inhibitory mechanism of SN-38, and indicate that clinically feasible drug combinations could be designed based on their interactions with Nrf2 signaling.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Bardoxolone 218600-44-3 C31H41NO4 150 suppliers $10.00-$2200.00
Bardoxolone 218600-44-3 C31H41NO4 150 suppliers $10.00-$2200.00
Bardoxolone 218600-44-3 C31H41NO4 150 suppliers $10.00-$2200.00
Bardoxolone 218600-44-3 C31H41NO4 150 suppliers $10.00-$2200.00

Similar articles

IF:7.7

The transcription factor FgCreA modulates ergosterol biosynthesis and sensitivity to DMI fungicides by regulating transcription of FgCyp51A and FgErg6A in Fusarium graminearum

International Journal of Biological Macromolecules Chenguang Wang, Pengfei Li,etc Published: 23 November 2024
IF:0.8

Andrographolide Induces Apoptosis in Gastric Cancer Cells through Reactivation of p53 and Inhibition of Mdm-2

Doklady Biochemistry and Biophysics Hongbo Gao, Hongyang Li,etc Published: 25 October 2021
IF:6.9

5-aza-2′-deoxycytidine induces telomere dysfunction in breast cancer cells

Biomedicine & Pharmacotherapy Sarah Al-dulaimi , Sheila Matta ,etc Published: 26 July 2024
怀柔区| 天门市| 奈曼旗| 巴楚县| 二连浩特市| 探索| 台东县| 长治县| 香格里拉县| 大竹县| 平果县| 江都市| 柘荣县| 翼城县| 禄丰县| 北安市| 安宁市| 兰溪市| 电白县| 普兰店市| 泾川县| 宕昌县| 夏津县| 贵定县| 五台县| 孙吴县| 建德市| 湖北省| 桐梓县| 从江县| 宁陕县| 安多县| 白玉县| 福泉市| 秭归县| 襄汾县| 阿鲁科尔沁旗| 琼结县| 汕尾市| 含山县| 杨浦区|