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Journal of Chemotherapy

Journal of Chemotherapy

IF: 1.8
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Antihyperlipidemic drug rosuvastatin suppressed tumor progression and potentiated chemosensitivity by downregulating CCNA2 in lung adenocarcinoma

Published:1 December 2024 DOI: 10.1080/1120009X.2024.2308975 PMID: 38288951
Xiang-Di Tan,?Cui-Fang Luo,?Si-Yu Liang

Abstract

Rosuvastatin (RSV) is widely used to treat hyperlipidemia and hypercholesterolemia and is recommended for the primary and secondary prevention of cardiovascular diseases (CVD). In this study, we aimed to explore its action and mechanism in lung adenocarcinoma (LUAD) therapy. Lewis and CMT64 cell-based murine subcutaneous LUAD models were employed to explore the effects of RSV monotherapy combined with cisplatin and gemcitabine. Human lung fibroblasts and human LUAD cell lines were used to assess the effects of RSV on normal and LUAD cells. Bioinformatics and RNA interference were used to observe the contribution of cyclin A2 (CCNA2) knockdown to RSV inhibition and to improve chemosensitivity in LUAD. RSV significantly suppressed grafted tumor growth in a murine subcutaneous LUAD model and exhibited synergistic anti-tumor activity with cisplatin and gemcitabine. In vitro and in?vivo experiments demonstrated that RSV impaired the proliferation and migration of cancer cells while showing little inhibition of normal lung cells. RNA interference and CCK8 detection preliminarily indicated that RSV inhibited tumor growth and enhanced the chemosensitivity to cisplatin and gemcitabine by downregulating CCNA2. RSV suppressed LUAD progression and enhanced chemosensitivity to cisplatin and gemcitabine by downregulating CCNA2, which should be prior consideration for the treatment of LUAD, especially for patients co-diagnosed with hyperlipidemia and hypercholesterolemia.

Substances (38)

Materials Related products
Procduct Name CAS Molecular Formula Supplier Price
Rosuvastatin calcium 147098-20-2 C22H30CaFN3O6S 966 suppliers $6.00-$1802.00
Rosuvastatin calcium 147098-20-2 C22H30CaFN3O6S 966 suppliers $6.00-$1802.00
Rosuvastatin calcium 147098-20-2 C22H30CaFN3O6S 966 suppliers $6.00-$1802.00
Rosuvastatin calcium 147098-20-2 C22H30CaFN3O6S 966 suppliers $6.00-$1802.00
Cisplatin 15663-27-1 Cl2H6N2Pt 922 suppliers $17.00-$7570.00
Cisplatin 15663-27-1 Cl2H6N2Pt 922 suppliers $17.00-$7570.00
Cisplatin 15663-27-1 Cl2H6N2Pt 922 suppliers $17.00-$7570.00
Cisplatin 15663-27-1 Cl2H6N2Pt 922 suppliers $17.00-$7570.00
Simvastatin 79902-63-9 C25H38O5 867 suppliers $5.00-$4900.00
Simvastatin 79902-63-9 C25H38O5 867 suppliers $5.00-$4900.00

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