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Developmental biology

Developmental biology

IF: 2.1
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Stage-specific regulation of undifferentiated spermatogonia by AKT1S1-mediated AKT-mTORC1 signaling during mouse spermatogenesis

Published:2 February 2024 DOI: 10.1016/j.ydbio.2024.02.002
Lele Yang , Jinyue Liao , Hongying Huang , Tin_Lap Lee , Huayu Qi

Abstract

Undifferentiated spermatogonia are composed of a heterogeneous cell population including spermatogonial stem cells (SSCs). Molecular mechanisms underlying the regulation of various spermatogonial cohorts during their self-renewal and differentiation are largely unclear. Here we show that AKT1S1, an AKT substrate and inhibitor of mTORC1, regulates the homeostasis of undifferentiated spermatogonia. Although deletion of Akt1s1 in mouse appears not grossly affecting steady-state spermatogenesis and male mice are fertile, the subset of differentiation-primed OCT4+ spermatogonia decreased significantly, whereas self-renewing GFRα1+ and proliferating PLZF+ spermatogonia were sustained. Both neonatal prospermatogonia and the first wave spermatogenesis were greatly reduced in Akt1s1?/? mice. Further analyses suggest that OCT4+ spermatogonia in Akt1s1?/? mice possess altered PI3K/AKT-mTORC1 signaling, gene expression and carbohydrate metabolism, leading to their functionally compromised developmental potential. Collectively, these results revealed an important role of AKT1S1 in mediating the stage-specific signals that regulate the self-renewal and differentiation of spermatogonia during mouse spermatogenesis.

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Materials Related products
Procduct Name CAS Molecular Formula Supplier Price
N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) 1477-57-2 C12H20Cl4N2O2 111 suppliers $15.00-$2200.00
N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) 1477-57-2 C12H20Cl4N2O2 111 suppliers $15.00-$2200.00
N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) 1477-57-2 C12H20Cl4N2O2 111 suppliers $15.00-$2200.00
N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) 1477-57-2 C12H20Cl4N2O2 111 suppliers $15.00-$2200.00

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