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BMJ : British Medical Journal

BMJ : British Medical Journal

IF: 105.7
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When I use a word . . . Medicines regulation-diethylene glycol.

Published:9 February 2024 DOI: 10.1136/bmj.q356 PMID: 38336378
Jeffrey K Aronson

Abstract

In 1937, when diethylene glycol was used as a solvent in the preparation of a medicinal product, an elixir of sulfanilamide, resulting in deaths, public outcry hastened the promulgation of an act that had been in preparation in the USA for several years, but which had met with opposition from pharmaceutical companies. The 1938 Food, Drug, and Cosmetics Act, as it was known, gave greater powers to the then recently formed Food and Drug Administration (FDA) in regulating the contents of medicinal formulations. Nevertheless, although similar regulatory systems have since been established around the world, episodes of poisoning with diethylene glycol in pharmaceutical formulations, whether deliberately included adulteration or as a contaminant, continue to be reported, generally in developing countries, usually affecting children, and often causing deaths.

Substances (2)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Diethylene glycol 111-46-6 C4H10O3 1245 suppliers $5.00-$6122.07
Sulfanilamide 63-74-1 C6H8N2O2S 743 suppliers $5.00-$6702.87

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