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Biomolecules

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Corticosterone Impairs Hippocampal Neurogenesis and Behaviors through p21-Mediated ROS Accumulation

Published:23 February 2024 DOI: 10.3390/biom14030268
Guanhao Wang, Lining Cao, Shuanqing Li, Meihui Zhang, Yingqi Li, Jinjin Duan, You Li, Zhangsen Hu, Jiaan Wu, Tianming Li, Ming Jiang, Jianfeng Lu

Abstract

Stress is known to induce a reduction in adult hippocampal neurogenesis (AHN) and anxiety-like behaviors. Glucocorticoids (GCs) are secreted in response to stress, and the hippocampus possesses the greatest levels of GC receptors, highlighting the potential of GCs in mediating stress-induced hippocampal alterations and behavior deficits. Herein, RNA-sequencing (RNA-seq) analysis of the hippocampus following corticosterone (CORT) exposure revealed the central regulatory role of the p21 (Cdkna1a) gene, which exhibited interactions with oxidative stress-related differentially expressed genes (DEGs), suggesting a potential link between p21 and oxidative stress-related pathways. Remarkably, p21-overexpression in the hippocampal dentate gyrus partially recapitulated CORT-induced phenotypes, including reactive oxygen species (ROS) accumulation, diminished AHN, dendritic atrophy, and the onset of anxiety-like behaviors. Significantly, inhibiting ROS exhibited a partial rescue of anxiety-like behaviors and hippocampal alterations induced by p21-overexpression, as well as those induced by CORT, underscoring the therapeutic potential of targeting ROS or p21 in the hippocampus as a promising avenue for mitigating anxiety disorders provoked by chronic stress.

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Materials Related products
Procduct Name CAS Molecular Formula Supplier Price
CORTICOSTERONE 50-22-6 C21H30O4 336 suppliers $32.00-$1010.00
CORTICOSTERONE 50-22-6 C21H30O4 336 suppliers $32.00-$1010.00
CORTICOSTERONE 50-22-6 C21H30O4 336 suppliers $32.00-$1010.00
CORTICOSTERONE 50-22-6 C21H30O4 336 suppliers $32.00-$1010.00
Corticosterone 50-22-6 - Inquiry
Corticosterone 50-22-6 - Inquiry
50-22-6 50-22-6 C21H30O4 - Inquiry
50-22-6 50-22-6 C21H30O4 - Inquiry

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