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Neural Regeneration Research

Neural Regeneration Research

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Tang Yong. et al. Activation of autophagy by Citri Reticulatae Semen extract ameliorates amyloid-beta-induced cell death and cognition deficits in Alzheimer’s disease. NEURAL REGEN RES. 2024 Jan;:10.4103/NRR.NRR

Published:31 January 2024 DOI: 10.4103/NRR.NRR-D-23-00954
Yong Tang, Jing Wei, Xiao-Fang Wang, Tao Long, Xiaohong Xiang, Liqun Qu, Xingxia Wang, Chonglin Yu, Xingli Xiao, Xueyuan Hu, Jing Zeng, Qin Xu, Anguo Wu, Jianming Wu, Dalian Qin, Xiaogang Zhou, Betty Yuen-Kwan Law

Abstract

figure1

Amyloid-beta-induced neuronal cell death contributes to cognitive decline in Alzheimer’s disease. Citri Reticulatae Semen has diverse beneficial effects on neurodegenerative diseases, including Parkinson’s and Huntington’s diseases, however, the effect of Citri Reticulatae Semen on Alzheimer’s disease remains unelucidated. In the current study, the anti-apoptotic and autophagic roles of Citri Reticulatae Semen extract on amyloid-beta-induced apoptosis in PC12 cells were first investigated. Citri Reticulatae Semen extract protected PC12 cells from amyloid-beta-induced apoptosis by attenuating the Bax/Bcl-2 ratio via activation of autophagy. In addition, Citri Reticulatae Semen extract was confirmed to bind amyloid-beta as revealed by biolayer interferometry in vitro, and suppress amyloid-beta-induced pathology such as paralysis, in a transgenic Caenorhabditis elegans in vivo model. Moreover, genetically defective Caenorhabditis elegans further confirmed that the neuroprotective effect of Citri Reticulatae Semen extract was autophagy-dependent. Most importantly, Citri Reticulatae Semen extract was confirmed to improve cognitive impairment, neuronal injury and amyloid-beta burden in 3×Tg Alzheimer’s disease mice. As revealed by both in vitro and in vivo models, these results suggest that Citri Reticulatae Semen extract is a potential natural therapeutic agent for Alzheimer’s disease via its neuroprotective autophagic effects.

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Materials
Procduct Name CAS Molecular Formula Supplier Price
3-METHYLADENINE 5142-23-4 C6H7N5 397 suppliers $12.00-$4500.00
3-METHYLADENINE 5142-23-4 C6H7N5 397 suppliers $12.00-$4500.00
3-METHYLADENINE 5142-23-4 C6H7N5 397 suppliers $12.00-$4500.00
3-METHYLADENINE 5142-23-4 C6H7N5 397 suppliers $12.00-$4500.00
3H-?Purin-?6-?amine, 3-?methyl- 5142-23-4 C6H7N5 - Inquiry
3H-?Purin-?6-?amine, 3-?methyl- 5142-23-4 C6H7N5 - Inquiry

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