一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Molecular immunology >>article
Molecular immunology

Molecular immunology

IF: 3
Download PDF

CXCL1-CXCR2 axis mediates inflammatory response after sciatic nerve injury by regulating macrophage infiltration

Published:16 March 2024 DOI: 10.1016/j.molimm.2024.03.006
Suli Jiang , Wei Li , Meiying Song , Jie Liang , Guixian Liu , Qiaochu Du , Luoyang Wang , Haining Meng , Lei Tang , Yanyan Yang , Bei Zhang

Abstract

Macrophages play a crucial role in the inflammatory response following sciatic nerve injury. Studies have demonstrated that C-X-C motif chemokine (CXCL) 1 recruit macrophages by binding to C-X-C chemokine receptor (CXCR) 2 and participates in the inflammatory response of various diseases. Based on these findings, we aimed to explore the role of the CXCL1-CXCR2 axis in the repair process after peripheral nerve injury. Initially, we simulated sciatic nerve injury and observed an increased expression of CXCL1 and CXCR2 in the nerves of the injury group. Both in vivo and in vitro experiments confirmed that the heightened CXCL1 expression occurs in Schwann cells and is secreted, while the elevated CXCR2 is expressed by recruited macrophages. In addition, in vitro experiments demonstrated that the binding of CXCL1 to CXCR2 can activate the NLRP3 inflammasome and promote the production of interleukin-1 beta (IL-1β) in macrophages. However, after mice were subjected to sciatic nerve injury, the number of macrophages and the expression of inflammatory factors in the sciatic nerve were reduced following treatment with the CXCR2 inhibitor SB225002. Simultaneously, we evaluated the sciatic nerve function index, the expression of p75 neurotrophic factor receptor (p75NTR), and myelin proteins, and all of these results were improved with the use of SB225002. Thus, our results suggest that after sciatic nerve injury, the CXCL1-CXCR2 axis mediates the inflammatory response by promoting the recruitment and activation of macrophages, which is detrimental to the repair of the injured nerves. In contrast, treatment with SB225002 promotes the repair of injured sciatic nerves.

Substances (5)

Materials Related products
Procduct Name CAS Molecular Formula Supplier Price
SB 225002 182498-32-4 C13H10BrN3O4 170 suppliers $12.00-$2180.00
SB 225002 182498-32-4 C13H10BrN3O4 170 suppliers $12.00-$2180.00

Similar articles

IF:2.9

TLR4 Inhibitor TAK‐242 Protected Henoch–Schonlein Purpura Nephritis in Rats by Regulating Inflammatory Response and Immune Competence via NF‐ κB/NLRP3 Signalling

Clinical and Experimental Pharmacology and Physiology Yirong Liu, Qiong Wu,etc Published: 20 November 2024
IF:3.2

PKN2 Promotes Peripheral Nerve Repair by Regulating Autophagy via Activation of the AKT‐mTOR Pathway: An In Vitro Study

Journal of Biochemical and Molecular Toxicology Lin Wang, Yuan‐sheng Huang,etc Published: 22 November 2024
IF:4.5

Grifola frondosa Polysaccharide Ameliorates Inflammation by Regulating Macrophage Polarization of Liver in Type 2 Diabetes Mellitus Rats

Molecular Nutrition & Food Research Pei Zou, Xueyan Li,etc Published: 26 November 2024
东莞市| 怀安县| 双桥区| 张北县| 承德市| 定陶县| 赤壁市| 江山市| 商都县| 精河县| 六盘水市| 靖西县| 阳江市| 高邮市| 特克斯县| 台北市| 夏邑县| 武清区| 靖西县| 新绛县| 青铜峡市| 洛隆县| 海宁市| 馆陶县| 三台县| 灯塔市| 玉溪市| 闻喜县| 双峰县| 克拉玛依市| 伊金霍洛旗| 满洲里市| 陆川县| 富川| 南安市| 江达县| 太原市| 山东省| 信宜市| 望谟县| 德令哈市|