一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Cell Communication and Signaling >>article
Cell Communication and Signaling

Cell Communication and Signaling

IF: 8.2
Download PDF

The c-Abl-RACK1-FAK signaling axis promotes renal fibrosis in mice through regulating fibroblast-myofibroblast transition

Published:30 April 2024 DOI: 10.1186/s12964-024-01603-z
Qianyi Bao, Anyu Wang, Wenxuan Hong, Yushu Wang, Baojie Li, Lin He, Xiaodong Yuan, Gang Ma

Abstract

Renal fibrosis is a prevalent manifestation of chronic kidney disease (CKD), and effective treatments for this disease are currently lacking. Myofibroblasts, which originate from interstitial fibroblasts, aggregate in the renal interstitium, leading to significant accumulation of extracellular matrix and impairment of renal function. The nonreceptor tyrosine kinase c-Abl (encoded by the Abl1 gene) has been implicated in the development of renal fibrosis. However, the precise role of c-Abl in this process and its involvement in fibroblast-myofibroblast transition (FMT) remain poorly understood. To investigate the effect of c-Abl in FMT during renal fibrosis, we investigated the expression of c-Abl in fibrotic renal tissues of patients with CKD and mouse models. We studied the phenotypic changes in fibroblast or myofibroblast-specific c-Abl conditional knockout mice. We explored the potential targets of c-Abl in NRK-49F fibroblasts. In this study, fibrotic mouse and cell models demonstrated that c-Abl deficiency in fibroblasts mitigated fibrosis by suppressing fibroblast activation, fibroblast-myofibroblast transition, and extracellular matrix deposition. Mechanistically, c-Abl maintains the stability of the RACK1 protein, which serves as a scaffold for proteins such as c-Abl and focal adhesion kinase at focal adhesions, driving fibroblast activation and differentiation during renal fibrosis. Moreover, specifically targeting c-Abl deletion in renal myofibroblasts could prove beneficial in established kidney fibrosis by reducing RACK1 expression and diminishing the extent of fibrosis. Our findings suggest that c-Abl plays a pathogenic role in interstitial fibrosis through the regulation of RACK1 protein stabilization and myofibroblast differentiation, suggesting a promising strategy for the treatment of CKD.

Substances (24)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Paclitaxel 33069-62-4 C47H51NO14 1284 suppliers $15.00-$4050.00
Paclitaxel 33069-62-4 C47H51NO14 1284 suppliers $15.00-$4050.00
Paclitaxel 33069-62-4 C47H51NO14 1284 suppliers $15.00-$4050.00
Paclitaxel 33069-62-4 C47H51NO14 1284 suppliers $15.00-$4050.00
MG-132 133407-82-6 C26H41N3O5 427 suppliers $11.00-$9807.90
MG-132 133407-82-6 C26H41N3O5 427 suppliers $11.00-$9807.90
MG-132 133407-82-6 C26H41N3O5 427 suppliers $11.00-$9807.90
MG-132 133407-82-6 C26H41N3O5 427 suppliers $11.00-$9807.90
BAFILOMYCIN A1 88899-55-2 C35H58O9 305 suppliers $80.00-$7612.00
BAFILOMYCIN A1 88899-55-2 C35H58O9 305 suppliers $80.00-$7612.00

Similar articles

IF:3.5

Conformational switches that control the TEC kinase – PLCγ signaling axis

Journal of Structural Biology: X Jacques Lowe, Raji E. Joseph,etc Published: 1 January 2022
IF:4.4

ACVR1 mediates renal tubular EMT in kidney fibrosis via AKT activation

Cellular signalling Tianli Yu, Zhangyu Mai,etc Published: 23 November 2024
IF:3.7

Curcumin and Especially Tetrahydrocurcumin Ameliorate Oxidative Stress-Induced Renal Injury in Mice

Journal of Nutrition Okada Kunihiko , Wangpoengtrakul Chantima ,etc Published: 1 August 2001
长治市| 汉寿县| 襄樊市| 望奎县| 阿坝县| 建昌县| 安岳县| 栾城县| 三明市| 蒲江县| 泸州市| 邹城市| 甘泉县| 颍上县| 五大连池市| 杂多县| 青浦区| 岳普湖县| 克拉玛依市| 奉新县| 巍山| 冕宁县| 海丰县| 蒙阴县| 宁国市| 原平市| 甘洛县| 即墨市| 新乡市| 张家港市| 洪江市| 潞城市| 甘南县| 德江县| 行唐县| 霍城县| 河北省| 柳州市| 鄯善县| 阜宁县| 大同市|