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Translational Oncology

Translational Oncology

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Demethylzeylasteral exerts potent efficacy against non-small-cell lung cancer via the P53 signaling pathway

Published:22 May 2024 DOI: 10.1016/j.tranon.2024.101989
Linxi Lv , Feng Zhou , Yizhou Quan , Yiwei Fan , Yunjia Bao , Yaning Dou , Hongyan Qu , Xuanxuan Dai , Haiyang Zhao , Suqing Zheng , Chengguang Zhao , Lehe Yang

Abstract

Lung cancer has one of the highest mortality rates worldwide, with non-small-cell lung cancer (NSCLC) constituting approximately 85% of all cases. Demethylzeylasteral (DEM), extracted from Tripterygium wilfordii Hook F, exhibits notable anti-tumor properties. In this study, we revealed that DEM could effectively induce NSCLC cell apoptosis. Specifically, DEM can dose-dependently suppress the viability and migration of human NSCLC cells. RNA-seq analysis revealed that DEM regulates the P53-signaling pathway, which was further validated by assessing crucial proteins involved in this pathway. Biacore analysis indicated that DEM has high affinity with the P53 protein. The CDX model demonstrated DEM's anti-tumor actions. This work provided evidence that DEM-P53 interaction stabilizes P53 protein and triggers downstream anti-tumor activities. These findings indicate that DEM treatment holds promise as a potential therapeutic approach for NSCLC, which warrants further clinical assessment in patients with NSCLC.

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Materials
Procduct Name CAS Molecular Formula Supplier Price
5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOL 213261-59-7 C14H12O3S2 162 suppliers $23.00-$2395.30
5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOL 213261-59-7 C14H12O3S2 162 suppliers $23.00-$2395.30
5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOL 213261-59-7 C14H12O3S2 162 suppliers $23.00-$2395.30
5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOL 213261-59-7 C14H12O3S2 162 suppliers $23.00-$2395.30
[5-[5-[5-(hydroxymethyl)thiophen-2-yl]furan-2-yl]thiophen-2-yl]methanol 213261-59-7 C14H12O3S2 - Inquiry
[5-[5-[5-(hydroxymethyl)thiophen-2-yl]furan-2-yl]thiophen-2-yl]methanol 213261-59-7 C14H12O3S2 - Inquiry

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