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Pharmacological research

Pharmacological research

IF: 9.1
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Diarylpropionitrile-stimulated ERβ nuclear accumulation promotes MyoD-induced muscle regeneration in mdx mice by interacting with FOXO3A

Published:30 August 2024 DOI: PMID: 39216837
Haowei Tong , Shusheng Fan , Wanting Hu , Huna Wang , Guangyao Guo , Xiaofei Huang , Lei Zhao , Xihua Li , Luyong Zhang , Zhenzhou Jiang , Qinwei Yu

Abstract

Duchenne muscular dystrophy (DMD) is an X-linked recessive progressive degenerative disease of skeletal muscle, characterized by intramuscular inflammation, muscle regeneration disorder and replacement of muscle with fibroadipose tissue. DMD is caused by the absence of normal dystrophy. Impaired self-renew ability and limited differentiation capacity of satellite cells are proved as main reasons for muscle regeneration failure. The deficiency of estrogen impedes the process of muscle regeneration. However, the role of estrogen receptor β (ERβ) in muscle regeneration is still unclear. This study aims to investigate the role and the pharmacological effect of ERβ activation on muscle regeneration in mdx mice. This study showed that mRNA levels of ERβ and myogenic-related genes both witnessed increasing trends in dystrophic context. Our results revealed that treatment with selective ERβ agonist (DPN, diarylpropionitrile) significantly increased myogenic differentiation 1 (MyoD-1) level and promoted muscle regeneration in mdx mice. Similarly, in mdx mice with muscle-specific estrogen receptor α (ERα) ablation, DPN treatment still promoted muscle regeneration. Moreover, we demonstrated that myoblasts differentiation was accompanied by raised nuclear accumulation of ERβ. DPN treatment augmented the nuclear accumulation of ERβ and, thus, contributed to myotubes formation. One important finding was that forkhead box O3A (FOXO3A), as a pivotal transcription factor in Myod-1 transcription, participated in the ERβ-promoted muscle regeneration. Overall, we offered an interesting explanation about the crucial role of ERβ during myogenesis.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
2,3-BIS(4-HYDROXYPHENYL)-PROPIONITRILE 1428-67-7 C15H13NO2 112 suppliers $39.00-$2487.00
2,3-BIS(4-HYDROXYPHENYL)-PROPIONITRILE 1428-67-7 C15H13NO2 112 suppliers $39.00-$2487.00
2,3-BIS(4-HYDROXYPHENYL)-PROPIONITRILE 1428-67-7 C15H13NO2 112 suppliers $39.00-$2487.00
2,3-BIS(4-HYDROXYPHENYL)-PROPIONITRILE 1428-67-7 C15H13NO2 112 suppliers $39.00-$2487.00

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