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Journal of Toxicologic Pathology

Journal of Toxicologic Pathology

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The role of mitochondrial reactive oxygen species in initiating mitochondrial damage and inflammation in wasp-venom-induced acute kidney injury

Published:11 September 2024 DOI: 10.1293/tox.2024-0046
Lingya XIA, Hai YUAN, Zhao GAO, Ying LV, Liang XU, Fengqi HU

Abstract

Acute kidney injury induced by stings?from?multiple?wasps is a medical emergency and is a driving factor of acute renal dysfunction. Numerous studies have shown that mitochondrial reactive oxygen species (mtROS) play a key role in ischemia-reperfusion injury-, cisplatin-, and sepsis-induced acute kidney injury. However, the?role?of?mtROS and?its?underlying mechanisms in wasp-venom-induced acute kidney injury remain inconclusive. In this study, we investigated the role and mechanisms of mtROS in mitochondrial damage and inflammation in a mouse model of acute kidney injury induced using wasp venom. Changes in mitochondrial function, transcription factor A (TFAM) expression, and DNA maintenance levels, renal function, stimulator of interferon gene (STING) expression, and inflammatory mediator levels in model mice with or without the mtROS scavenger Mito-Tempo were analyzed in?vivo. Downregulation of mtROS levels reversed renal damage and mitochondrial dysfunction, and reduced STING expression and inflammation in the kidneys of model mice. The suppression of mtROS levels also improved the decrease in TFAM levels and mitochondrial DNA copy numbers in the kidneys of the model mice. In summary, the existing evidence in this study shows that mtROS contribute significantly?to mitochondrial damage and inflammation in acute kidney injury induced by wasp venom.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Mito-TEMPO 1334850-99-5 C29H35N2O2P 106 suppliers $34.00-$4469.30
Mito-TEMPO 1334850-99-5 C29H35N2O2P 106 suppliers $34.00-$4469.30
Mito-TEMPO 1334850-99-5 C29H35N2O2P 106 suppliers $34.00-$4469.30
Mito-TEMPO 1334850-99-5 C29H35N2O2P 106 suppliers $34.00-$4469.30

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