一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> iScience >>article
iScience

iScience

IF: 4.6
Download PDF

Patient-derived rhabdomyosarcoma cells recapitulate the genetic and transcriptomic landscapes of primary tumors

Published:31 August 2024 DOI: 10.1016/j.isci.2024.110862
Yuxiang Hu , Ziqi He , Shuangai Liu , Wenwen Ying , Yifan Chen , Manli Zhao , Min He , Xuan Wu , Yinbing Tang , Weizhong Gu , Meidan Ying , Jinhu Wang , Ting Tao

Abstract

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in childhood and adolescence. The availability of appropriate and well-characterized preclinical models for RMS is limited, posing a challenge for investigating the molecular mechanisms and evaluating new targeted compounds in preclinical settings. Here, we collected 51 RMS specimens (referred to as ZJUCH-RMS cohort) and established 9 patient-derived cells (PDCs) and validated the identity of these cells by the expression of RMS-specific markers. Whole-transcriptome analysis identified high-confidence mutations in ZJUCH-RMS cohort including RAS, TP53, ARID1A, MYOD1, and MYCN. Further studies showed that RMS PDCs retained the genetic alterations and the expression of RMS hallmark and dependency genes in matched primary tumors and acted as valuable tools to assess drug responses and pharmacogenomic interactions. Our study provides unique PDCs that are available for preclinical studies of RMS and further advances the feasibility of RMS PDCs as valuable tools for developing personalized treatments for patients.

Similar articles

IF:19.8

Generation of iPSC-derived human venous endothelial cells for the modeling of vascular malformations and drug discovery

Cell stem cell Zihang Pan, Qiyang Yao,etc Published: 22 November 2024
IF:2.4

Maltose: The primary signal of hunger and satiation in human beings

Physiology & Behavior John M. Poothullil,etc Published: 1 July 1992
IF:6.9

Biogenesis of the peptide-derived redox cofactor pyrroloquinoline quinone

Current Opinion in Chemical Biology Wen Zhu , Judith P. Klinman,etc Published: 1 December 2020
高要市| 玛多县| 波密县| 凤阳县| 同仁县| 米泉市| 马山县| 华容县| 北海市| 松潘县| 新和县| 手游| 沈丘县| 长垣县| 红安县| 惠州市| 朔州市| 莫力| 天峻县| 青神县| 五指山市| 商城县| 周宁县| 周宁县| 梓潼县| 祁连县| 柏乡县| 通道| 贡山| 阿尔山市| 无为县| 太仆寺旗| 临汾市| 桃园市| 称多县| 吴堡县| 剑阁县| 连江县| 永定县| 阿瓦提县| 五原县|