一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Rejuvenation research >>article
Rejuvenation research

Rejuvenation research

IF: 2.6
Download PDF

Wedelolactone attenuates liver fibrosis and hepatic stellate cell activation by suppressing the Hippo pathway

Published:14 September 2024 DOI: 10.1089/rej.2024.0053
Wei Zhang,Kai Gao,Ya Bai,Dong Xu,Meina Zhao,Xingru Tao,Jingwen Wang

Abstract

Liver fibrosis is a commonly observed pathological phenomenon that occurs during the progression of various types of chronic liver diseases. The Hippo pathway is closely associated with the pathogenesis of liver fibrosis. Previous studies have shown that wedelolactone (WED) has a significant anti-hepatic fibrosis effect, whereas the target and mechanism underlying WED remain elusive. In this study, we found that WED significantly alleviated liver fibrosis and injury by inhibiting the expression of YAP and TAZ. In an in vitro model, WED suppressed the activation of hepatic stellate cells (HSCs) induced by TGF-β1, as well as the mRNA and protein expression of α-SMA, YAP, and TAZ. The allosteric regulation of YAP by WED was confirmed using MD and CETSA. Moreover, specific knockdown or inhibition of YAP did not enhance the suppressive effect of WED on HSC activation or protein expression associated with fibrosis. These findings demonstrated that the administration of WED effectively alleviated liver fibrosis by suppressing the Hippo/YAP/TAZ pathways. In addition, YAP activity may be regulated by WED via allosteric regulation.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Verteporfin 129497-78-5 2C41H42N4O8 253 suppliers $24.00-$5308.00
Verteporfin 129497-78-5 2C41H42N4O8 253 suppliers $24.00-$5308.00
Verteporfin 129497-78-5 2C41H42N4O8 253 suppliers $24.00-$5308.00
Verteporfin 129497-78-5 2C41H42N4O8 253 suppliers $24.00-$5308.00

Similar articles

IF:5.2

L-Histidine attenuates NEFA-induced inflammatory responses by suppressing Gab2 expression

Life sciences Mengze Li , Huiying Wang ,etc Published: 4 May 2024
IF:6.7

Pharmacokinetics and anti-liver fibrosis characteristics of amygdalin: Key role of the deglycosylated metabolite prunasin

Phytomedicine Congcong Zhang , Dingqi Zhang ,etc Published: 1 May 2022
阿尔山市| 马尔康县| 习水县| 乌拉特前旗| 青海省| 华宁县| 西丰县| 壤塘县| 庆城县| 抚远县| 亳州市| 江门市| 绵阳市| 平定县| 杭锦后旗| 淮阳县| 新宁县| 全州县| 苏尼特左旗| 荆门市| 迭部县| 鹤庆县| 康马县| 昌江| 吴旗县| 曲麻莱县| 荃湾区| 奈曼旗| 西乌珠穆沁旗| 额敏县| 巴彦淖尔市| 荆州市| 新源县| 遂平县| 乌拉特后旗| 前郭尔| 台山市| 鹤岗市| 临夏县| 武威市| 威信县|