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Science Advances

Science Advances

IF: 11.7
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Generation and characterization of giant panda induced pluripotent stem cells

Published:20 September 2024 DOI: 10.1126/sciadv.adn7724
Yuliang Liu, Shihao Zhang, Gaoyang Zou, Junhui An, Yuan Li, Danni Lin, Donghui Wang, Yan Li, Jiasong Chen, Tongying Feng, Hongyan Li, Yijiao Chen, Mingyue Zhang, Manish Kumar, Luqin Wang, Rong Hou, Jing Liu

Abstract

The giant panda (Ailuropoda melanoleuca) stands as a flagship and umbrella species, symbolizing global biodiversity. While traditional assisted reproductive technology faces constraints in safeguarding the genetic diversity of giant pandas, induced pluripotent stem cells (iPSCs) known for their capacity to differentiate into diverse cells types, including germ cells, present a transformative potential for conservation of endangered animals. In this study, primary fibroblast cells were isolated from the giant panda, and giant panda iPSCs (GPiPSCs) were generated using a non-integrating episomal vector reprogramming method. Characterization of these GPiPSCs revealed their state of primed pluripotency and demonstrated their potential for differentiation. Furthermore, we innovatively formulated a species-specific chemically defined FACL medium and unraveled the intricate signaling pathway networks responsible for maintaining the pluripotency and fostering cell proliferation of GPiPSCs. This study provides key insights into rare species iPSCs, offering materials for panda characteristics research and laying the groundwork for in vitro giant panda gamete generation, potentially aiding endangered species conservation.

Substances (10)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Y-27632 DIHYDROCHLORIDE 146986-50-7 C14H21N3O 277 suppliers $16.00-$2691.10
Y-27632 DIHYDROCHLORIDE 146986-50-7 C14H21N3O 277 suppliers $16.00-$2691.10
Y-27632 DIHYDROCHLORIDE 146986-50-7 C14H21N3O 277 suppliers $16.00-$2691.10
Y-27632 DIHYDROCHLORIDE 146986-50-7 C14H21N3O 277 suppliers $16.00-$2691.10
GSK-LSD1 1431368-48-7 C14H20N2 73 suppliers $44.00-$1700.00
GSK-LSD1 1431368-48-7 C14H20N2 73 suppliers $44.00-$1700.00
GSK-LSD1 1431368-48-7 C14H20N2 73 suppliers $44.00-$1700.00
GSK-LSD1 1431368-48-7 C14H20N2 73 suppliers $44.00-$1700.00
GSK-LSD1 1431368-48-7 11 suppliers Inquiry
GSK-LSD1 1431368-48-7 11 suppliers Inquiry

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