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Communications Biology

Communications Biology

IF: 5.2
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Cpt1a Drives primed-to-na?ve pluripotency transition through lipid remodeling.

Published:30 September 2024 DOI:
Zhaoyi Ma, Xingnan Huang, Junqi Kuang, Qiannan Wang, Yue Qin, Tao Huang, Zechuan Liang, Wei Li, Yu Fu, Pengli Li, Yixin Fan, Ziwei Zhai, Xiaomin Wang, Jin Ming, Chengchen Zhao, Bo Wang, Duanqing Pei

Abstract

Metabolism has been implicated in cell fate determination, particularly through epigenetic modifications. Similarly, lipid remodeling also plays a role in regulating cell fate. Here, we present comprehensive lipidomics analysis during BMP4-driven primed to naive pluripotency transition or BiPNT and demonstrate that lipid remodeling plays an essential role. We further identify Cpt1a as a rate-limiting factor in BiPNT, driving lipid remodeling and metabolic reprogramming while simultaneously increasing intracellular acetyl-CoA levels and enhancing H3K27ac at chromatin open sites. Perturbation of BiPNT by histone acetylation inhibitors suppresses lipid remodeling and pluripotency transition. Together, our study suggests that lipid remodeling promotes pluripotency transitions and further regulates cell fate decisions, implicating Cpt1a as a critical regulator between primed-naive cell fate control. The metabolomic landscape characterizing the PNT process elucidates the crucial role of CPT1A in driving lipid remodeling, thereby regulating the transition of cellular fate

Substances (16)

Materials
Procduct Name CAS Molecular Formula Supplier Price
CHIR-99021 252917-06-9 C22H18Cl2N8 343 suppliers $28.00-$4401.00
CHIR-99021 252917-06-9 C22H18Cl2N8 343 suppliers $28.00-$4401.00
CHIR-99021 252917-06-9 C22H18Cl2N8 343 suppliers $28.00-$4401.00
CHIR-99021 252917-06-9 C22H18Cl2N8 343 suppliers $28.00-$4401.00
PD 0325901 391210-10-9 C16H14F3IN2O4 287 suppliers $8.00-$3990.00
PD 0325901 391210-10-9 C16H14F3IN2O4 287 suppliers $8.00-$3990.00
PD 0325901 391210-10-9 C16H14F3IN2O4 287 suppliers $8.00-$3990.00
PD 0325901 391210-10-9 C16H14F3IN2O4 287 suppliers $8.00-$3990.00
Tazemetostat 1403254-99-8 C34H44N4O4 242 suppliers $9.00-$2062.50
Tazemetostat 1403254-99-8 C34H44N4O4 242 suppliers $9.00-$2062.50

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