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Biochemical pharmacology

Biochemical pharmacology

IF: 5.3
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Aspirin increases estrogen levels in the placenta to prevent preeclampsia by regulating placental metabolism and transport function

Published:27 September 2024 DOI: 10.1016/j.bcp.2024.116561 PMID: 39343179
Shengbo Huang , Yuan Xu , Yuanqing Guo , Yuanjin Zhang, Yu Tang, Chenmeizi Liang, Liangcai Gao, Bingyi Yao, Xin Wang

Abstract

Preeclampsia is a unique multisystem progressive disease during pregnancy, which seriously endangers the health of pregnant women and fetuses. In clinical practice, aspirin is recommended for the prevention of preeclampsia, but the mechanism by which aspirin prevents preeclampsia has not yet been revealed. This report comprehensively evaluates the effects of aspirin on the expression and activity of placental metabolic enzymes and transporters. We found that after aspirin administration, only the expression of organic anion transporter 4 (OAT4) in the placenta showed a significant increase at both mRNA and protein levels, consistent with the results in JAR cells. Meanwhile, studies on the metabolic enzyme activity in the placenta showed a high upregulation of CYP19A1 activity. Subsequently, significant increases in endogenous substrates of OAT4 and CYP19A1 (dehydroepiandrosterone sulfate (DHEAS) and androstenedione) as well as estrone were detected in placental tissue. In summary, aspirin enhances the transport of DHEAS through OAT4 and promotes the metabolism of androstenedione through CYP19A1, thereby increasing estrogen levels in the placenta. This may be the mechanism by which aspirin prevents preeclampsia and maintains pregnancy by regulating the metabolism and transport function of the placenta.

Substances (12)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Estrone 53-16-7 C18H22O2 702 suppliers $10.00-$1510.00
Estrone 53-16-7 C18H22O2 702 suppliers $10.00-$1510.00
Estrone 53-16-7 C18H22O2 702 suppliers $10.00-$1510.00
Estrone 53-16-7 C18H22O2 702 suppliers $10.00-$1510.00
DHEA-S 651-48-9 C19H28O5S 42 suppliers $30.00-$812.00
DHEA-S 651-48-9 C19H28O5S 42 suppliers $30.00-$812.00
DHEA-S 651-48-9 C19H28O5S 42 suppliers $30.00-$812.00
DHEA-S 651-48-9 C19H28O5S 42 suppliers $30.00-$812.00
1,3,5(10)-Estratrien-3-ol-17-one 53-16-7 - Inquiry
1,3,5(10)-Estratrien-3-ol-17-one 53-16-7 - Inquiry

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