一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Aquatic Toxicology >>article
Aquatic Toxicology

Aquatic Toxicology

IF: 4.1
Download PDF

Possible mechanisms for adverse effects on zebrafish sperm and testes associated with low-level chronic PFOA exposure

Published:26 September 2024 DOI: 10.1016/j.aquatox.2024.107108 PMID: 39366191
Yuhan Wang , Yu Huo , Afrasyab Khan, Ningna Ma, Weijun Mai

Abstract

Perfluorooctanoic acid (PFOA), which is widely used during the manufacturing of fluoropolymer coatings and polytetrafluoroethylene, is now a widespread pollutant in the environment and within the human body. This study used zebrafish, an aquatic model species, to investigate how low levels of chronic PFOA exposure affect the reproductive system. The results of the experiments in which zebrafish were exposed to 414 ng/L or 4140 ng/L for 60 days showed a variety of adverse effects on testicular tissue and sperm, including dose-dependent changes in plasma estradiol and testosterone levels, various sperm malformations, decreased sperm motility and concentration, and PFOA-induced oxidative stress and testicular damage with increased rates of apoptosis. In addition, offspring of the zebrafish that had been exposed to PFOA were characterized by increased malformation and mortality. Subsequent transcriptional analyses of the male gonads revealed the significant activation of oxidative stress bioprocesses and immuno-inflammatory signaling pathways, along with the dysregulation of reproductive bioprocesses. In conclusion, low-level chronic exposure to PFOA affects both the reproductive performance of adults and the development of offspring; the mechanisms for these adverse effects involve alterations in several molecular pathways that may be involved in PFOA-induced oxidative stress and reproductive abnormalities. The presented data can be used to assess the ecotoxicity of PFOA to the male reproductive system at environmentally-relevant concentrations.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Pentadecafluorooctanoic acid 335-67-1 C8HF15O2 421 suppliers $10.00-$1495.00
Pentadecafluorooctanoic acid 335-67-1 C8HF15O2 421 suppliers $10.00-$1495.00
Pentadecafluorooctanoic acid 335-67-1 C8HF15O2 421 suppliers $10.00-$1495.00
Pentadecafluorooctanoic acid 335-67-1 C8HF15O2 421 suppliers $10.00-$1495.00

Similar articles

IF:0

Gestational diabetes mellitus is associated with a low serum level of mitochondrial-derived peptide-MOTS-C

Turk biyokimya dergisi = Turkish journal of biochemistry Serdar ?zer, Filiz Alkan Baylan,etc Published: 21 September 2023
IF:2.1

Effects of chronic stavudine exposure on liver, pancreas and kidneys of pregnant rats and their fetuses: Morphological and biochemical aspects

European journal of obstetrics, gynecology, and reproductive biology Regina Lúcia Braga Barreto , José Maria Soares Jr. ,etc Published: 1 September 2006
IF:8.1

Adverse cardiovascular effects of long-term exposure to diethyl phthalate in the rat aorta

Chemosphere Melissa Mariana , Margarida Lorigo ,etc Published: 1 November 2023
沧州市| 舟曲县| 天峻县| 天峨县| 达日县| 靖远县| 蒙城县| 屯留县| 达日县| 长垣县| 土默特左旗| 宣威市| 崇阳县| 隆化县| 自贡市| 诏安县| 普兰县| 滨州市| 个旧市| 象山县| 枣强县| 衡阳市| 锦屏县| 高邑县| 张家港市| 通州市| 安陆市| 英吉沙县| 合阳县| 桑日县| 波密县| 江城| 镶黄旗| 吉林省| 寿宁县| 德州市| 五莲县| 衡东县| 应用必备| 建德市| 隆德县|