一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Brain, Behavior, and Immunity >>article
Brain, Behavior, and Immunity

Brain, Behavior, and Immunity

IF: 8.8
Download PDF

Social isolation promotes tumor immune evasion via β2-adrenergic receptor

Published:12 October 2024 DOI: 10.1016/j.bbi.2024.10.012
Xueqin Zhao , Fei Li , Chen Cheng , Mingyue Bi , Jing Li , Jingjing Cong , Xuefu Wang

Abstract

Social isolation is a recognized risk factor for tumor initiation and mortality, but the role and mechanisms responsible for social isolation on tumor progression are poorly understood. In this study, we found that social isolation contributed to accelerated tumor growth and induced a remodeling of the tumor immune microenvironment, resulting in immunosuppression. Mechanistically, social isolation triggered the activation of the sympathetic nervous system, leading to impaired CD8+ T cell antitumor immune responses by activating β-adrenergic receptor 2 (β2-AR), which highly expressed on tumor-infiltrating CD8+ T cells. Pharmacological inhibition of β2-AR signaling effectively enhanced CD8+ T cell anti-tumor immune responses and improved the efficacy of anti-PD-1 immunotherapy in the context of social isolation. Thus, our study uncovers a mechanism through which social isolation induces tumor immune evasion and offers potential directions for cancer immunotherapy in socially isolated patients.

Substances (28)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Mifepristone 84371-65-3 C29H35NO2 595 suppliers $5.00-$1593.90
Mifepristone 84371-65-3 C29H35NO2 595 suppliers $5.00-$1593.90
Mifepristone 84371-65-3 C29H35NO2 595 suppliers $5.00-$1593.90
Mifepristone 84371-65-3 C29H35NO2 595 suppliers $5.00-$1593.90
Norepinephrine 51-41-2 C8H11NO3 342 suppliers $40.00-$1650.00
Norepinephrine 51-41-2 C8H11NO3 342 suppliers $40.00-$1650.00
Norepinephrine 51-41-2 C8H11NO3 342 suppliers $40.00-$1650.00
Norepinephrine 51-41-2 C8H11NO3 342 suppliers $40.00-$1650.00
6-HYDROXYDOPAMINE HYDROCHLORIDE 28094-15-7 C8H12ClNO3 144 suppliers $48.00-$2035.00
6-HYDROXYDOPAMINE HYDROCHLORIDE 28094-15-7 C8H12ClNO3 144 suppliers $48.00-$2035.00

Similar articles

IF:2.6

Sphingosine-1-phosphate receptor 3 promotes neuronal apoptosis via the TNF-α/caspase-3 signaling pathway after acute intracerebral hemorrhage

Molecular and Cellular Neuroscience Dengpan Song, Mengyuan Li,etc Published: 22 November 2024
IF:10.7

Label‐Free Prediction of Tumor Metastatic Potential via Ramanome

Small Methods Yuxing Zhang, Yanmei Zhang,etc Published: 19 November 2024
IF:5.7

The transdermal cream of Formestane anti-breast cancer by controlling PI3K-Akt pathway and the tumor immune microenvironment.

Frontiers in Immunology Lanyang Gao, Lei Zhu,etc Published: 1 January 2023
宁远县| 周至县| 山西省| 阜康市| 吴江市| 彩票| 汪清县| 庆阳市| 博爱县| 河西区| 油尖旺区| 方正县| 海南省| 昌平区| 平阴县| 伽师县| 通许县| 酒泉市| 徐汇区| 阿拉尔市| 陆良县| 丽江市| 靖宇县| 濮阳市| 鹿邑县| 凤庆县| 托克逊县| 新巴尔虎左旗| 柘荣县| 北安市| 保康县| 施秉县| 仪陇县| 新化县| 兴山县| 邵武市| 安义县| 保康县| 巴林左旗| 保亭| 曲阜市|