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Brain, Behavior, and Immunity

Brain, Behavior, and Immunity

IF: 8.8
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Social isolation promotes tumor immune evasion via β2-adrenergic receptor

Published:12 October 2024 DOI: 10.1016/j.bbi.2024.10.012
Xueqin Zhao , Fei Li , Chen Cheng , Mingyue Bi , Jing Li , Jingjing Cong , Xuefu Wang

Abstract

Social isolation is a recognized risk factor for tumor initiation and mortality, but the role and mechanisms responsible for social isolation on tumor progression are poorly understood. In this study, we found that social isolation contributed to accelerated tumor growth and induced a remodeling of the tumor immune microenvironment, resulting in immunosuppression. Mechanistically, social isolation triggered the activation of the sympathetic nervous system, leading to impaired CD8+ T cell antitumor immune responses by activating β-adrenergic receptor 2 (β2-AR), which highly expressed on tumor-infiltrating CD8+ T cells. Pharmacological inhibition of β2-AR signaling effectively enhanced CD8+ T cell anti-tumor immune responses and improved the efficacy of anti-PD-1 immunotherapy in the context of social isolation. Thus, our study uncovers a mechanism through which social isolation induces tumor immune evasion and offers potential directions for cancer immunotherapy in socially isolated patients.

Substances (28)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Mifepristone 84371-65-3 C29H35NO2 595 suppliers $5.00-$1593.90
Mifepristone 84371-65-3 C29H35NO2 595 suppliers $5.00-$1593.90
Mifepristone 84371-65-3 C29H35NO2 595 suppliers $5.00-$1593.90
Mifepristone 84371-65-3 C29H35NO2 595 suppliers $5.00-$1593.90
Norepinephrine 51-41-2 C8H11NO3 342 suppliers $40.00-$1650.00
Norepinephrine 51-41-2 C8H11NO3 342 suppliers $40.00-$1650.00
Norepinephrine 51-41-2 C8H11NO3 342 suppliers $40.00-$1650.00
Norepinephrine 51-41-2 C8H11NO3 342 suppliers $40.00-$1650.00
6-HYDROXYDOPAMINE HYDROCHLORIDE 28094-15-7 C8H12ClNO3 144 suppliers $48.00-$2035.00
6-HYDROXYDOPAMINE HYDROCHLORIDE 28094-15-7 C8H12ClNO3 144 suppliers $48.00-$2035.00

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