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Current Issues in Molecular Biology

Current Issues in Molecular Biology

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Homosalate and ERK Knockdown in the Modulation of Aurelia coerulea Metamorphosis by Regulating the PI3K Pathway and ERK Pathway

Published:18 October 2024 DOI: 10.3390/cimb46100690 PMID: 39451570
Jinhong Chen,?Xiaoyu Geng,?Bingbing Li,?Jinyao Xie,?Jieying Ma,?Zhen Qin,?Mingke Wang,?Jishun Yang

Abstract

Metamorphosis control is pivotal in preventing the outbreak of jellyfish, and it is often studied using common model organisms. The widespread use of the ultraviolet blocking agent homosalate in cosmetics poses a threat to marine ecosystems. Although the impact of homosalate on marine organisms has been extensively examined, there is a notable absence of research on its effects on jellyfish metamorphosis and the underlying mechanisms, warranting further investigation. In this study, we first established a study model by using 5-methoxy-2-methylindole to induce Aurelia coerulea metamorphosis, and selected homosalate as a PI3K agonist and an ERK agonist, while we used YS-49 as a specific PI3K agonist, as well as ERK knockdown, to observe their effect on the metamorphosis of Aurelia coerulea. The results showed that an Aurelia coerulea metamorphosis model was established successfully, and the PI3K agonist homosalate, YS-49, and the knockdown of ERK molecules could significantly delay the metamorphosis development of Aurelia coerulea. We propose that activating PI3K/Akt and inhibiting the ERK pathway are involved in the delayed development of Aurelia coerulea, which provides a new strategy for the prevention and control of jellyfish blooms.

Substances (16)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Homosalate 118-56-9 C16H22O3 366 suppliers $10.00-$1309.78
Homosalate 118-56-9 C16H22O3 366 suppliers $10.00-$1309.78
Homosalate 118-56-9 C16H22O3 366 suppliers $10.00-$1309.78
Homosalate 118-56-9 C16H22O3 366 suppliers $10.00-$1309.78
YS 49 132836-42-1 C20H20BrNO2 93 suppliers $53.00-$1800.00
YS 49 132836-42-1 C20H20BrNO2 93 suppliers $53.00-$1800.00
YS 49 132836-42-1 C20H20BrNO2 93 suppliers $53.00-$1800.00
YS 49 132836-42-1 C20H20BrNO2 93 suppliers $53.00-$1800.00
YS-49 (Monohydrate) 132836-42-1 C??H??BrNO? 9 suppliers Inquiry
YS-49 (Monohydrate) 132836-42-1 C??H??BrNO? 9 suppliers Inquiry

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