一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Scientific Reports >>article
Scientific Reports

Scientific Reports

IF: 3.8
Download PDF

Synergistic effects of bloom helicase (BLM) inhibitor AO/854 with cisplatin in prostate cancer

Published:23 October 2024 DOI: 10.1038/s41598-024-75938-5 PMID: 39438537
Xiaoyan Ma,?Fu Tian,?Yuanpin Xiao,?Mengqiu Huang,?Dandan Song,?Xinlin Chen,?Houqiang Xu

Abstract

To determine the synergistic effect and mechanism of AO/854, a new Bloom syndrome protein (BLM) helicase inhibitor, and cisplatin (CDDP), a DNA-crosslinking agent, cell viability assays, neutral comet assays, and Western blotting (WB) were performed on prostate cancer (PCa) cells. According to our findings, combining AO/854 and CDDP enhanced the antiproliferative capabilities of PC3 cell lines. As evidenced by the upregulation of γH2AX, cleaved caspase-3/caspase-3, and BAX/Bcl-2, AO/854 dramatically increased PC3 apoptosis and DNA damage induced by CDDP. Furthermore, combining AO/854 and CDDP synergistically inhibited PC3 cell migration and invasion. In addition, AO/854 inhibited CDDP-induced S-phase cell-cycle arrest in PC3 cells while enhancing G2/M-phase cell-cycle arrest. In vivo, the antitumor efficacy of the combination therapy group was greater than that of the groups treated with AO/854 or CDDP alone. Our findings indicate that synergistic chemotherapy with AO/854 and CDDP may be a novel anticancer strategy for PCa.

Substances (6)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Cisplatin 15663-27-1 Cl2H6N2Pt 920 suppliers $14.00-$7570.00
Cisplatin 15663-27-1 Cl2H6N2Pt 920 suppliers $14.00-$7570.00
Cisplatin 15663-27-1 Cl2H6N2Pt 920 suppliers $14.00-$7570.00
Cisplatin 15663-27-1 Cl2H6N2Pt 920 suppliers $14.00-$7570.00
Cisplatin 15663-27-1 - Inquiry
Cisplatin 15663-27-1 - Inquiry

Similar articles

IF:4.2

Cisplatin in cancer therapy: Molecular mechanisms of action

European journal of pharmacology Shaloam Dasari, Paul Bernard Tchounwou,etc Published: 5 October 2014
IF:7.7

Fe-coordinated carbon dots with single atom nanozyme catalytic activity for synergistic catalytic/chemo-therapy in breast cancer

International Journal of Biological Macromolecules Mengke Lu, Jianxia Ding,etc Published: 1 December 2024
衢州市| 防城港市| 平陆县| 石棉县| 汨罗市| 高雄市| 桦川县| 建宁县| 滨州市| 遂宁市| 三穗县| 昌宁县| 北宁市| 安远县| 武城县| 湘潭县| 临武县| 灵宝市| 吉安县| 上饶县| 大连市| 车致| 新营市| 互助| 周至县| 冷水江市| 镇平县| 如东县| 武强县| 临夏县| 巫溪县| 岳西县| 裕民县| 平武县| 灯塔市| 平江县| 卢龙县| 保康县| 巴林左旗| 南溪县| 高碑店市|