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Biology Direct

Biology Direct

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NID1 promotes laryngeal cancer stemness via activating WNT pathway

Published:13 November 2024 DOI: 10.1186/s13062-024-00548-0 PMID: 39538332
Wenlin Liu,?Jie Wu,?Yuanpu Lai,?Siyi Zhang,?Ankui Yang,?Yixuan Li,?Cuifang Chen,?Zhongming Lu

Abstract

Background: Laryngeal cancer (LCA) is one of the most common head and neck squamous cell carcinoma with poor outcome. LCA stem cells are the main reason for LCA therapy resistance and relapse. Understanding the molecular mechanisms of the self-renew of LCA stem cells is critical to develop now targets and strategies for LCA therapy.

Methods: Q-PCR and western blotting assays were used to determine NID1 level in LCA tissues and normal laryngeal tissues. MTT, colony formation assay, apoptosis assay and animal model were used to investigate the effect of NID1 on radiotherapy resistance. Side population assay and sphere formation assay were used to determine the role of LCA in the self-renew of LCA stem cells.

Results: NID1 was upregulated in LCA tissues, particularly in LCA tissues derived from relapsed patients, and associated with had poor outcome. NID1 knockdown suppressed radiotherapy resistance and the self-renew of LCA stem cells, while NID1 overexpression promoted radiotherapy resistance and the self-renew of LCA stem cells. Further analysis showed that NID1 promotes radiotherapy resistance and the self-renew of LCA stem cells via activating WNT pathway. Moreover, NID1 level was positively correlated with nuclear β-Catenin level in LCA tissues.

Conclusion: Our results show that NID1 promotes radiotherapy resistance and the self-renew of LCA stem cells via activating WNT pathway, providing a novel potential target for LCA treatment.

Substances (8)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Verapamil 52-53-9 C27H38N2O4 162 suppliers $29.00-$43100.00
Verapamil 52-53-9 C27H38N2O4 162 suppliers $29.00-$43100.00
Verapamil 52-53-9 C27H38N2O4 162 suppliers $29.00-$43100.00
Verapamil 52-53-9 C27H38N2O4 162 suppliers $29.00-$43100.00
PUROMYCIN 53-79-2 C22H29N7O5 146 suppliers $39.00-$1200.00
PUROMYCIN 53-79-2 C22H29N7O5 146 suppliers $39.00-$1200.00
PUROMYCIN 53-79-2 C22H29N7O5 146 suppliers $39.00-$1200.00
PUROMYCIN 53-79-2 C22H29N7O5 146 suppliers $39.00-$1200.00

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