一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Molecular Psychiatry >>article
Molecular Psychiatry

Molecular Psychiatry

IF: 9.6
Download PDF

Prefrontal parvalbumin interneurons mediate CRHR1-dependent early-life stress-induced cognitive deficits in adolescent male mice

Published:22 November 2024 DOI: 10.1038/s41380-024-02845-6
Ma, Yu-Nu, Yang, Chao-Juan, Zhang, Chen-Chen, Sun, Ya-Xin, Yao, Xing-Duo, Liu, Xiao, Li, Xue-Xin, Wang, Hong-Li, Wang, Han, Wang, Ting, Wang, Xiao-Dong, Zhang, Chen, Su, Yun-Ai, Li, Ji-Tao, Si, Tian-Mei

Abstract

Cognitive impairment, a core symptom of psychiatric disorders, is frequently observed in adolescents exposed to early-life stress (ES). However, the underlying neural mechanisms are unclear, and therapeutic efficacy is limited. Targeting parvalbumin-expressing interneurons (PVIs) in the medial prefrontal cortex (mPFC), we report that ES reduces mPFC PVI activity, which causally mediated ES-induced cognitive deficits in adolescent male mice through chemogenetic and optogenetic experiments. To understand the possible causes of PVI activity reduction following ES, we then demonstrated that ES upregulated corticotropin-releasing hormone (CRH) receptor 1 [CRHR1, mainly expressed in pyramidal neurons (PNs)] and reduced activity of local pyramidal neurons (PNs) and their excitatory inputs to PVIs. The subsequent genetic manipulation experiments (CRHR1 knockout, CRH overexpression, and chemogenetics) highlight that ES-induced PVI activity reduction may result from CRHR1 upregulation and PN activity downregulation and that PVIs play indispensable roles in CRHR1- or PN-mediated cognitive deficits induced by ES. These results suggest that ES-induced cognitive deficits could be attributed to the prefrontal CRHR1-PN-PVI pathway. Finally, treatment with antalarmin (a CRHR1 antagonist) and environmental enrichment successfully restored the PVI activity and cognitive deficits induced by ES. These findings reveal the neurobiological mechanisms underlying ES-induced cognitive deficits in adolescent male mice and highlight the therapeutic potentials of PVIs in stress-related cognitive deficits in adolescent individuals.

Substances (2)

Materials
Procduct Name CAS Molecular Formula Supplier Price
β-Cyclodextrin 7585-39-9 C42H70O35 769 suppliers $9.00-$1810.00
2,2,2-Tribromoethanol 75-80-9 C2H3Br3O 299 suppliers $6.00-$1094.12

Similar articles

IF:3.7

Curcumin and Especially Tetrahydrocurcumin Ameliorate Oxidative Stress-Induced Renal Injury in Mice

Journal of Nutrition Okada Kunihiko , Wangpoengtrakul Chantima ,etc Published: 1 August 2001
IF:5.6

AICAR Improves Outcomes of Metabolic Syndrome and Type 2 Diabetes Induced by High-Fat Diet in C57Bl/6 Male Mice.

International Journal of Molecular Sciences Elena A Tukhovskaya, Elvira R Shaykhutdinova,etc Published: 11 December 2022
宿州市| 大关县| 磐安县| 沽源县| 宜阳县| 新昌县| 镇原县| 泗水县| 乌兰浩特市| 陇川县| 偏关县| 通江县| 应用必备| 斗六市| 招远市| 武义县| 荣昌县| 通化县| 汨罗市| 大关县| 调兵山市| 岳阳市| 治县。| 新宁县| 天峻县| 亳州市| 常熟市| 福清市| 长丰县| 二连浩特市| 甘肃省| 沈丘县| 永泰县| 乳源| 平塘县| 保康县| 池州市| 石林| 广元市| 定兴县| 增城市|