一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Advanced Science >>article
Advanced Science

Advanced Science

IF: 14.3
Download PDF

Synthesis of Closely‐Contacted Cu2O‐CoWO4 Nanosheet Composites for Cuproptosis Therapy to Tumors With Sonodynamic and Photothermal Assistance

Published:21 November 2024 DOI: 10.1002/advs.202410621 PMID: 39573907
Zhuoran Yang, Zhuo Li, Chunyu Yang, Li Meng, Wei Guo, Liqiang Jing

Abstract

Cuproptosis offers a promising and selective therapeutic strategy for cancer therapy. To fully realize its potential, the development of novel cuproptosis therapeutic agents and the achievement of efficient copper release are critical steps forward. Herein, closely-contacted Cu2O-CoWO4 nanosheet heterojunctions (CCW-NH) are successfully synthesized using an in-situ process for cuproptosis therapy. The efficient release of copper ions from CCW-NH can be triggered by ultrasound irradiation, primarily due to the generation of superoxide radicals as the sonodynamic agents via the Z-scheme charge transfer mechanism. When subjected to the combined effects of ultrasound and laser irradiation, the effective release of copper ions is increased by 1.7 times compared to the untreated group, significantly enhancing the efficiency of cuproptosis. And the incorporation of CCW-NH and L-arginine into the temperature-sensitive injectable hydrogel (HP-CCW@LA) ultimately achieved a tumor inhibition rate of up to 95.1%. L-arginine, serving as a reducing agent, enabled the sustained release of highly active Cu+ during treatment. Notably, after treating tumors with HP-CCW@LA, the tumor microenvironment is leveraged to promote copper ion conversion, which offers the potential for monitoring tumor therapy efficacy through magnetic resonance imaging. This work offers a novel integrated strategy for the development of new cuproptosis agents and therapeutic evaluation.

Substances (3)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Thiazolyl Blue 298-93-1 C18H16N5S.Br 613 suppliers $7.00-$5262.50
2′,7′-Dichlorodihydrofluorescein Diacetate 4091-99-0 C24H16Cl2O7 292 suppliers $16.00-$270980.00
CALCEIN-AM 148504-34-1 C46H46N2O23 221 suppliers $73.00-$2740.00

Similar articles

卫辉市| 读书| 商河县| 类乌齐县| 瓮安县| 吉安市| 霸州市| 察雅县| 诸城市| 格尔木市| 称多县| 济阳县| 乌兰察布市| 吉首市| 曲沃县| 沂南县| 高台县| 胶州市| 年辖:市辖区| 昌邑市| 梧州市| 垣曲县| 松阳县| 蓬溪县| 新竹市| 吴江市| 繁昌县| 自贡市| 陆河县| 柳江县| 井研县| 宜阳县| 庐江县| 望城县| 阳信县| 玉环县| 治县。| 泰兴市| 方山县| 罗甸县| 浮梁县|