一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Advanced Science >>article
Advanced Science

Advanced Science

IF: 14.3
Download PDF

Postbiotics From Lactobacillus Johnsonii Activates Gut Innate Immunity to Mitigate Alcohol‐Associated Liver Disease

Published:22 November 2024 DOI: 10.1002/advs.202405781 PMID: 39574408
Ruopeng Yin, Tao Wang, Jingzu Sun, Huanqin Dai, Yuting Zhang, Ningning Liu, Hongwei Liu

Abstract

Prolonged alcohol consumption disrupts the gut microbiota and the immune system, contributing to the pathogenesis of alcohol-associated liver disease (ALD). Probiotic-postbiotic intervention strategies can effectively relieve ALD by maintaining gut homeostasis. Herein, the efficacy of heat-killed Lactobacillus johnsonii (HKLJ) in mitigating alcoholic liver damage is demonstrated in mouse models of ALD. The gut-liver axis is identified as a pivotal pathway for the protective effects of L. johnsonii against ALD. Specifically, HKLJ is found to upregulate the expression of intestinal lysozymes, thereby enhancing the production of immunoregulatory substances from gut bacteria, which subsequently activated the Nucleotide-binding oligomerization domain 2 (NOD2)-interleukin (IL-23)-IL-22 innate immune axis. The elevated IL-22 upregulated the antimicrobial peptide synthesis to maintain intestinal homeostasis and moreover activated the Signal transducer and activator of Transcription3 (STAT3) pathway in the liver to facilitate the repair of hepatic injuries. The heat-killed L. johnsonii provoked immunity helps correct the gut microbiota dysbiosis, specifically by reversing the reduction of butyrate-producing bacteria (such as Faecalibaculum rodentium) and the expansion of opportunistic pathogens (such as Helicobacter sp. and Pichia kudriavzevii) induced by ethanol. The findings provide novel insights into the gut microbiota-liver axis that may be leveraged to enhance the treatment of ALD.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Trypsin 9002-07-7 C35H47N7O10 739 suppliers $19.90-$73956.00
Proteinase K 39450-01-6 C29H27N2O12P 726 suppliers $28.00-$10680.00
Maltodextrin 9050-36-6 C12H22O11 614 suppliers $14.00-$4750.00
Solvent Red 27 1320-06-5 C26H24N4O 377 suppliers $10.00-$1440.00

Similar articles

IF:2.9

Therapeutic role of ursodeoxycholic acid in colitis-associated cancer via gut microbiota modulation.

ACS Chemical Health & Safety Qilang He,?Jinjie Wu,etc Published: 1 February 2023
IF:1.8

Immunity to coccidiosis after treatment with toltrazuril.

Parasitology Research G Greif,etc Published: 1 October 2000
元氏县| 乌兰县| 黄平县| 信宜市| 太和县| 克什克腾旗| 固始县| 石狮市| 洛隆县| 行唐县| 连南| 安塞县| 潞城市| 新民市| 新建县| 高要市| 阜宁县| 开平市| 兴山县| 兖州市| 云安县| 永济市| 罗平县| 株洲县| 民县| 安吉县| 大宁县| 田林县| 淮北市| 崇礼县| 阳信县| 西贡区| 武胜县| 葫芦岛市| 安图县| 昭苏县| 湘潭市| 两当县| 武夷山市| 敦煌市| 永康市|