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Additive manufacturing

Additive manufacturing

IF: 10.3
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Numerical model of jet formation during melt electrowriting for fabrication of precise structures

Published:25 September 2024 DOI: 10.1016/j.addma.2024.104569
Xiaodan Huo, Huinan Lai, Xiaona Lin

Abstract

Melt electrowriting (MEW) is an innovative technique for fabricating 3D porous materials or scaffolds with microscale architectures. However, the multitude of printing parameters makes precise control over the placement of microscale polymer fibers challenging. This study presents a new strategy for creating complex 3D structures using multiparametric MEW technology, which enhances printing accuracy with minimal human intervention. We developed and validated a numerical model to simulate jet formation and predict the critical translational speed (CTS). This model can precisely identify the effects of numerous printing parameters and improve printing efficiency and accuracy while reducing costs, thus facilitating precise MEW deposition. Using this approach, we manufactured soft, stretchable constructs with a high surface area optimized through fine-tuned printing parameters. This straightforward and efficient technology enables the design of high-sensitivity strain sensors for monitoring human motion and stretchable devices for circuit protection. Furthermore, we examined the effect of printing accuracy and fiber orientation on cellular organization. Immunochemical staining demonstrated that aligned and high-precision scaffolds promote oriented growth. Additionally, the curved MEW structures open new avenues for exploring the combined effects of topographical cues and mechanical stimulation on nerve cell behaviors. This printing strategy provides valuable insights for future research on complex patterns using MEW for flexible electronics and tissue engineering.

Substances (6)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Retinoic acid 302-79-4 C20H28O2 986 suppliers $5.00-$5434.00
4',6-Diamidino-2-phenylindole dihydrochloride 28718-90-3 C16H16ClN5 610 suppliers $15.00-$4800.00
Penicillin G sodium salt 69-57-8 C16H17N2NaO4S 523 suppliers $12.00-$1449.25
Polycaprolactone 24980-41-4 C6H10O2 320 suppliers $10.00-$1671.33
Streptomycin 57-92-1 C21H39N7O12 160 suppliers Inquiry
FETUIN 9014-81-7 NULL 92 suppliers $37.07-$4810.00

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