一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Journal of Food Science >>article
Journal of Food Science

Journal of Food Science

IF: 3.2
Download PDF

Optimizing Lactiplantibacillus plantarum viability in the gastrointestinal tract and its impact on gut microbiota–brain axis through zein microencapsulation

Published:24 November 2024 DOI: 10.1111/1750-3841.17368 PMID: 39581595
Jie Zeng, Yang Lyu, Xueying Huang, Ho‐Kit Leung, Shanting Zhao, Jianzhuo Zhang, Yi Wang, David Y. Wang

Abstract

Evidence suggests that Lactiplantibacillus plantarum (LP) can positively influence gut microbiota, subsequently affecting brain function via the gut-brain axis. However, the oral administration of LP may subject it to damage from gastric acid. To address this issue, a microencapsulation system was developed to protect LP and enhance its viability in the gastrointestinal tract. In the study, zein-microencapsulated LP (MLP) was prepared using the phase separation method. We found that the optimal conditions to encapsulate LP (9?log?CFU/mL) were a zein concentration of 10?mg/mL and a zein-to-bacteria mass ratio of 5:1. Scanning electron microscopy and dynamic light scattering analysis demonstrated that MLP exhibited a microstructure with an approximate diameter of 4?μm. Findings also revealed that microencapsulation markedly improved the in vitro survival rate of LP compared to free cells and allowed for controlled release. Subsequent in vivo studies in mice showed that this encapsulation not only boosted the colonization of LP but also ameliorated the imbalance of gut microbiota associated with depression. An analysis of the intestinal microbiota in mice identified 13 genera that exhibited significant shifts in abundance due to the depressive states. The administration of MLP reversed these microbial changes, underscoring its therapeutic potential. Additionally, the study examined the expression of pro-inflammatory cytokines. The administrated MLP was found to reverse the inflammation in both the intestine and hippocampus of mice with depression. Behavioral assessments in mouse models corroborated the efficacy of MLP in preventing depression, positioning it as a promising daily supplement.

Substances (3)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Trehalose 99-20-7 C12H22O11 653 suppliers $6.00-$581.37
Alginic acid 9005-32-7 (C6H8O6)n 383 suppliers $10.16-$780.00
Zein 9010-66-6 N/A 343 suppliers $14.00-$1060.00
独山县| 金乡县| 固原市| 萨迦县| 介休市| 绥滨县| 射洪县| 洛川县| 凌云县| 潞城市| 辽宁省| 宝兴县| 明水县| 萨迦县| 奉新县| 顺平县| 永胜县| 资溪县| 巴马| 梁山县| 靖远县| 永城市| 中宁县| 阿巴嘎旗| 油尖旺区| 黔西县| 托里县| 苏尼特左旗| 丹江口市| 晋州市| 酒泉市| 循化| 江安县| 大同县| 怀来县| 塔城市| 扎囊县| 灵璧县| 扶余县| 嘉义县| 永州市|