一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Fitoterapia >>article
Fitoterapia

Fitoterapia

IF: 2.5
Download PDF

Tracheloside, the main constituent of the total lignan extract from Trachelospermi Caulis, inhibited rheumatoid arthritis via IL-17/MAPK signaling pathway

Published:26 November 2024 DOI: 10.1016/j.fitote.2024.106311
He-Fei Wang, Zi-Hong Huang, Qin-Gang Tan

Abstract

A quantitative analysis method was established using high-performance liquid chromatography (HPLC) to simultaneously determine five lignans in the total lignan extract (TLE) from Trachelospermi Caulis at 280?nm, including nortracheloside, tracheloside, nortrachelogenin, trachelogenin, and arctigenin. The method demonstrated good linearity for each lignan within their respective ranges, with precision, stability, and repeatability meeting the criteria for quantitative analysis. Tracheloside, the most abundant compound in the TLE, effectively inhibited the release of inflammatory factors IL-6 and IL-17, and suppressed the migration MH7A cells in vitro. Furthermore, tracheloside reduced the production of key inflammatory factors, including COX-2, IL-6, IL-17, MMP2, MMP3, MMP9, JNK, p-JNK, p38, and p-p38 in TNF-α induced MH7A cells, thereby inhibiting the IL-17/MAPK signaling pathway, and thus contributing to its anti-rheumatoid arthritis effects. This study represents the first report on the simultaneous quantification of five major lignans from Trachelospermi Caulis and the anti-inflammatory properties of tracheloside.

Similar articles

IF:2.4

Equol promotes the in vitro maturation of porcine oocytes by activating the NRF2/KEAP1 signaling pathway

Theriogenology Sai Xiao, Ke Peng,etc Published: 22 November 2024
IF:7.7

The transcription factor FgCreA modulates ergosterol biosynthesis and sensitivity to DMI fungicides by regulating transcription of FgCyp51A and FgErg6A in Fusarium graminearum

International Journal of Biological Macromolecules Chenguang Wang, Pengfei Li,etc Published: 23 November 2024
凤城市| 湄潭县| 纳雍县| 灵丘县| 鸡东县| 策勒县| 新和县| 岳阳市| 蕲春县| 梧州市| 台州市| 武胜县| 四子王旗| 砀山县| 开封县| 怀集县| 任丘市| 临城县| 封丘县| 益阳市| 雷波县| 车致| 崇阳县| 吉安县| 兰考县| 宁海县| 高平市| 德格县| 孙吴县| 襄垣县| 通海县| 岳阳县| 正镶白旗| 瑞丽市| 巴东县| 太仆寺旗| 新兴县| 万荣县| 墨玉县| 苗栗市| 翁牛特旗|