一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Neuroscience >>article
Neuroscience

Neuroscience

IF: 2.9
Download PDF

Dihydromyricetin ameliorates neurotoxicity induced by high glucose through restraining ferroptosis by inhibiting JNK-inflammation pathway in HT22 cells

Published:25 November 2024 DOI: 10.1016/j.neuroscience.2024.11.061 PMID: 39603402
Li-ting Peng, Meng-wei Li, Hong-yan Ling

Abstract

Diabetes mellitus is recognized as an important cause of cognitive dysfunction. Ferroptosis plays a key role in diabetic cognitive dysfunction (DCD). Dihydromyricetin (DHM) has promising neuronal protective effects, but it is unclear the mechanism. Here, the effects of DHM on HG-induced neurotoxicity in HT22 cells and its molecular mechanisms were investigated. Our results demonstrated that the viability of HG (125?mmol/L)-induced HT22 cells was significantly decreased. Furthermore, ferroptosis-related indicators, c-Jun N-terminal kinase (JNK)-inflammatory pathway, TNF-α, IL-1β, and mitochondrial morphology were measured. The results show that mitochondria of HT22 cells also showed wrinkled alterations in response to HG treatment. Meanwhile, the levels of glutathione (GSH) and glutathione peroxidase 4 (GPX4) were decreased, accompanied by an up-regulation of malondialdehyde (MDA), Fe2+, acyl-CoA synthetase long-chain family member 4 (ACSL4), and reactive oxygen species (ROS), indicating ferroptosis occurred in HG-induced HT22 cells. Furthermore, the levels of p-JNK, TNF-α, and IL-6 were up-regulated in HG-induced HT22 cells. DHM or JNK inhibitor SP600125 reversed these changes in HG-induced HT22 cells indicating that HG-induced neurotoxicity in HT22 cells may be associated with ferroptosis induced by the JNK-inflammatory factor pathway. Meanwhile, JNK agonist Anisomycin could attenuate these effects of DHM. Taken together, our data suggest that DHM can ameliorate HG-induced neurotoxicity in HT22 cells by inhibiting ferroptosis via the JNK-inflammatory signaling pathway. Hence, DHM may represent a novel and promising therapeutic intervention for DCD.

Substances (1)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Dihydromunduletone 674786-20-0 C25H28O6 20 suppliers Inquiry

Similar articles

IF:3.3

Curcumin ameliorates astrocyte inflammation through AXL in cuprizone-induced mice

Toxicology and applied pharmacology Wenjing Zhang, Mengjiao Sun,etc Published: 23 November 2024
IF:2.9

A Brief Review of Neurotoxicity Induced by Melamine.

Neurotoxicity Research Lei An, Wei Sun,etc Published: 1 August 2017
津南区| 太和县| 英吉沙县| 宁夏| 淮滨县| 沾益县| 泸定县| 金昌市| 永安市| 雅安市| 许昌县| 汉中市| 方山县| 南平市| 南投市| 大新县| 龙岩市| 会泽县| 双峰县| 怀化市| 漠河县| 泸溪县| 武山县| 西乡县| 广灵县| 临高县| 林口县| 仁化县| 正镶白旗| 台江县| 宁海县| 乐至县| 克东县| 晋江市| 禹州市| 郸城县| 莫力| 当涂县| 文水县| 绩溪县| 新沂市|