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Veterinary Quarterly

Veterinary Quarterly

IF: 7.9
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Holstein× Montbéliarde-sired F1 generation crossbred female calves have an increased cellular immune response potential compared with purebred Holsteins

Published:1 December 2024 DOI: 10.1080/01652176.2024.2435982 PMID: 39625805
Zhipeng Zhang,?Chen Yu,?Zhi Chen,?Ping Hou,?Jie Sun,?Chunhua Yang,?Yu Tian,?Zhangping Yang,?Yi Yang,?Shaobin Shang

Abstract

It is well known that crossbreds show many advantages over purebreds in improving calf health traits, but the immunological factors responsible for this heterosis remain largely unclear. The objective of this study was to compare the cellular immune responses and antibodies of Holstein (HO) and Montbéliarde-sired?×?Holstein (MH) F1 generation female calves, and investigate the effects of crossbreeding on the immunity. Fifty three-month-old healthy female calves (25 HO, 25?MH) were selected meticulously in a farm with the same criteria. Subsequently, complete blood count, flow cytometric analysis of T cell subsets and intracellular IFN-γ production, as well as indirect ELISA analysis of antibodies were performed in order to determine the immune profiles of the two groups of calves. We found that MH calves had higher percentage and number of CD4+ and CD8+ T cells than HO calves in the peripheral blood (p?+ and CD8+ T cells (p?+ and CD8+ T cells from MH calves secreted more IFN-γ than that of HO calves (p?

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Tetramethylbenzidine 54827-17-7 C16H20N2 712 suppliers $6.00-$16430.00

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