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ACS Applied Materials & Interfaces

ACS Applied Materials & Interfaces

IF: 8.3
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GSH-Depleting and H2O2 Self-Supplying Calcium Peroxide-Based Nanoplatforms for Efficient Bacterial Eradication via Photothermal-Enhanced Chemodynamic?…

Published:6 December 2024 DOI: 10.1021/acsami.4c17388
Fuqiang Shi, Jie Chen, Lesan Yan, Jing Tu

Abstract

Chemodynamic therapy (CDT), an innovative approach for treating bacterial infections, has garnered significant attention due to its ability to generate hydroxyl radicals (?OH) via Fenton/Fenton-like reactions. However, the effectiveness of CDT is considerably hindered by the limited availability of endogenous hydrogen peroxide (H2O2) and the overexpression of glutathione (GSH) within the infection microenvironment. To address these limitations, a multifunctional nanoplatform with self-supplying H2O2, GSH-depletion properties, and photothermal properties was developed through a straightforward and mild strategy. This platform employs calcium peroxide (CaO2) as the core, coated with silica (SiO2) to enhance stability and further modified with a Cu(II)-doped polydopamine (PDA) layer, forming a core–shell structured CaO2@SiO2@PDA-Cu (CSPC). The Cu(II) released by CSPC, combined with the H2O2 produced from CaO2 degradation, participates in a Fenton-like reaction to generate toxic ?OH radicals. Additionally, Cu(II)-mediated redox reactions deplete overexpressed GSH, thereby enhancing CDT efficacy. Upon coordination with Cu(II), the photothermal properties of PDA are significantly enhanced, achieving a photothermal conversion efficiency of up to 43%. The hyperthermia induced by photothermal therapy (PTT) further increases ?OH production, augmenting CDT. The CSPC nanomaterials demonstrated outstanding synergistic photothermal bactericidal activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) at 60 μg/mL, achieving complete eradication. Moreover, CSPC eliminated 65.90 ± 3.46% of the S. aureus biofilm under near-infrared (NIR) irradiation. In vivo experiments demonstrated that CSPC treatment effectively eradicated bacteria, with a bacterial survival rate of 6.56 ± 3.28%, and accelerated wound healing, reducing the relative wound size to 7.0 ± 2.6%. Therefore, this study successfully developed versatile nanomaterials that significantly enhance the PTT/CDT dual-mode antibacterial performance.

Substances (8)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Sodium chloride 7647-14-5 ClNa 1689 suppliers $5.00-$6678.62
Sodium hydroxide 1310-73-2 NaOH 1356 suppliers $14.00-$17490.00
Polyvinylpyrrolidone 9003-39-8 CH4 1048 suppliers $15.00-$9201.92
Ethanol 64-17-5 C2H6O 955 suppliers $10.00-$28350.00
Methanol 67-56-1 CH4O 895 suppliers $9.00-$7620.00
Dopamine hydrochloride 62-31-7 C8H12ClNO2 772 suppliers $7.00-$2055.90
Ethyl silicate 78-10-4 C8H20O4Si 505 suppliers $12.00-$3300.00
Methylene Blue 61-73-4 C16H18ClN3S 460 suppliers $5.00-$3070.00

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