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Advanced Materials

IF: 27.4
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Multifunctional Microneedle Patches Loaded With Engineered Nitric Oxide‐Releasing Nanocarriers for Targeted and Synergistic Chronic Wound Therapy

Published:6 December 2024 DOI: 10.1002/adma.202413108
Yinli Jin, Shuhua Liu, Xueyang Wang, Chenyuan Wang, Qiongfang Ruan, Wei Li

Abstract

Chronic wounds impose significant physical and mental burdens on patients. Nano-based formulations offer a promising strategy for chronic wound healing due to their non-invasive nature and enhanced biofilms penetration, but they often lack targeting capability or fail to achieve long-term and synergistic effects. In this work, a multifunctional microneedle (MN) patch loaded with engineered nitric oxide (NO)-releasing nanocarriers are presented that encapsulate an antibacterial agent and are immobilized with Concanavalin A (Con A) and NO molecules for targeted and synergistic treatment of chronic wounds. With the assistance of MNs, the nanoparticles (NPs) can directly cross bacterial biofilms and be efficiently delivered to wound tissues, where they target harmful bacteria through the specific recognition between Con A and polysaccharides on bacterial surfaces, followed by the release of the encapsulated antimicrobial agent, thereby achieving effective antibacterial effect. Moreover, the NPs generate NO in a sustained manner as they dissociate in the wound tissue, which exerts potent anti-inflammatory action and benefits tissue regeneration, further promoting chronic wounds closure. Consequently, this work provides a novel MN patch loaded with engineered NPs designed for accelerating chronic wound healing through targeted and synergistic therapy.

Substances (9)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Calcium chloride 10043-52-4 CaCl2 1215 suppliers $5.00-$26371.00
N-Hydroxysuccinimide 6066-82-6 C4H5NO3 1030 suppliers $4.00-$4605.50
Sucrose 57-50-1 C12H22O11 1022 suppliers $5.00-$8400.00
Sodium alginate 9005-38-3 C5H7O4COONa 794 suppliers $12.70-$4105.00
DL-Tryptophan 54-12-6 C11H12N2O2 464 suppliers $6.00-$3937.50
D-Cysteine hydrochloride 32443-99-5 C3H7NO2S.ClH.H2O 395 suppliers $9.00-$2381.00
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide 1892-57-5 C8H17N3 386 suppliers $5.00-$2862.08
FETUIN 9014-81-7 NULL 92 suppliers $37.07-$4810.00
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