一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Biosensors and Bioelectronics >>article
Biosensors and Bioelectronics

Biosensors and Bioelectronics

IF: 10.7
Download PDF

Digital Microfluidics with Integrated Raman Sensor for High-Sensitivity In-Situ Bioanalysis

Published:4 December 2024 DOI: 10.1016/j.bios.2024.117036 PMID: 39657552
Wenbo Dong,?Rongxin Fu,?Nan Zhang,?Jing Zhao,?Yudan Ma,?Han Cui,?Jiangjiang Zhang,?Zipeng Zhao,?Hang Li,?Yunxia Zhao,?Yao Lu,?Zhizhong Chen,?Tianming Xu,?Huikai Xie,?Qian Yu,?Shuailong Zhang

Abstract

This study introduces an advanced bioanalytical platform that combines digital microfluidics (DMF) with Raman spectroscopy, effectively addressing common issues in bioanalysis such as sample contamination, excessive consumption of samples and reagents, and manual handling. Our innovative system is engineered to handle diverse sample types and enables both sample preparation and in-situ analysis on a single device, utilizing less than 5?μL of samples and reagents. It incorporates a Translucent Raman Enhancement Stack (TRES) sensor, which boosts the detection signal, and includes droplet-driving functionality for automated processing of complex samples in a compact setting. The hydrophilic surface of the TRES sensor draws analytes into the detection zone, expediting sample attachment and enhancing the surface-enhanced Raman scattering (SERS). Moreover, the TRES sensors are cost-effective, straightforward to manufacture, and scalable, making them suitable for widespread production and single-use bioanalytical applications. This integrated and automated approach streamlines the sample preparation and analysis processes, enhances detection efficiency, and achieves high sensitivity, excellent linearity, and effective detection of different biochemical analytes. We validate the system's accuracy through on-device enrichment and analysis of exosomes from serum, demonstrating its capability for real-time, on-site analysis of complex biological samples.

Substances (3)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Rhodamine B 81-88-9 C28H31ClN2O3 653 suppliers $8.00-$1735.00
Penicillin G sodium salt 69-57-8 C16H17N2NaO4S 520 suppliers $12.00-$1409.00
INSULIN 11061-68-0 C257H383N65O77S6 349 suppliers $48.00-$3420.00

Similar articles

IF:3.4

Electrochemical Sensor for the Determination of Methylthiouracil in Meat Samples.

Sensors Andrea Marco, Antonio Canals,etc Published: 15 November 2022
IF:0

A Self-Healing Integrated All-in-One Zinc-Ion Battery

Angewandte Chemie Dr. Shuo Huang, Dr. Fang Wan,etc Published: 30 January 2019
IF:27.4

Tumor‐Specific Protein Induced in Situ Self‐Assembly of Peptide Drugs for Synergistic Mitochondria Disruption

Advanced Materials Yi Hao, Da‐Yong Hou,etc Published: 27 November 2024
汽车| 中阳县| 新和县| 乌鲁木齐县| 淮安市| 特克斯县| 沁水县| 育儿| 清流县| 阜新| 赣榆县| 黄冈市| 仙桃市| 江华| 新宁县| 泸定县| 贡觉县| 久治县| 伊春市| 新密市| 从江县| 怀化市| 来安县| 大庆市| 子洲县| 长春市| 民乐县| 鄂托克旗| 缙云县| 洪江市| 东乡族自治县| 高青县| 凤山市| 江永县| 长宁县| 卓资县| 彭水| 南城县| 肇源县| 行唐县| 紫阳县|