一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Journal of Hazardous Materials >>article
Journal of Hazardous Materials

Journal of Hazardous Materials

IF: 12.2
Download PDF

Exposure to oxygenated polycyclic aromatic hydrocarbons and endocrine dysfunction: Multi-level study based on hormone receptor responses

Published:12 December 2024 DOI: 10.1016/j.jhazmat.2024.136855
Ying Ren, Yue Wang, Yang Wang, Xia Ning, Guangke Li, Nan Sang

Abstract

Oxygenated polycyclic aromatic hydrocarbons (OPAHs) are a class of emerging environmental contaminants that exhibit high toxicity compared to parent PAHs. In addition to carcinogenic, teratogenic and mutagenic effects, recent studies show their potential to cause endocrine disruption, but the reports are controversial. In this study, we employed hormone receptors (ERα/AR/GRα/TRβ)-mediated dual luciferase reporter gene assay and molecular docking, and found that five typical OPAHs exhibited agonistic activity towards hormone receptors, and hydrogen bonding and hydrophobic interactions are the primary binding forces involved in OPAHs-receptor interactions. Then, we developed a weighted scoring system coupled with computerized screening and clarified that 1,2-benzanthraquinone (BAQ) had the strongest hormonal effects, while anthraquinone (AQ) exhibited the weakest effects. Using the in vivo exposure-response model, we clarified that BAQ induced hormone receptor-coupled developmental toxicity in zebrafish larvae, evidenced by increased expression of androgen receptors and key genes involved in hormone synthesis, pericardial edema, and reduced body length. Importantly, we successfully constructed androgen response element-enhanced green fluorescent protein (ARE-EGFP) transient transfection zebrafish embryos, and confirmed the androgenic potency of BAQ, but not AQ. These findings highlight the endocrine-disrupting effects in the risk management of OPAHs.

Substances (1)

Materials
Procduct Name CAS Molecular Formula Supplier Price
1-PHENYL-2-THIOUREA 103-85-5 C7H8N2S 335 suppliers $5.00-$1183.00

Similar articles

IF:2.7

Assessment of glufosinate-containing herbicide exposure: A multi-center retrospective study

American Journal of Emergency Medicine Jen-Tso Hsiao MD , Hsiu-Yung Pan MD ,etc Published: 1 December 2021
IF:6.5

From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health1

American Journal of Clinical Nutrition Anthony W Norman,etc Published: 1 August 2008
大姚县| 交城县| 海南省| 宝鸡市| 临沂市| 河源市| 白沙| 礼泉县| 罗甸县| 翼城县| 卓资县| 滦平县| 金川县| 阆中市| 石狮市| 视频| 清涧县| 类乌齐县| 赤水市| 古交市| 平远县| 庆城县| 泌阳县| 元氏县| 东山县| 苍溪县| 石泉县| 额济纳旗| 三亚市| 略阳县| 璧山县| 呼伦贝尔市| 蚌埠市| 襄樊市| 云阳县| 拜城县| 鸡西市| 乐清市| 舒城县| 宝清县| 麻江县|