一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Advanced Science >>article
Advanced Science

Advanced Science

IF: 14.3
Download PDF

Triplet Electron Exchange in Carbon Nanodots‐assisted Long‐persistent near‐infrared Chemiluminescence for Oncology Synergistic Imaging and Therapy

Published:11 December 2024 DOI: 10.1002/advs.202411898 PMID: 39661728
Run-Wei Song,?Tian-Ci Jiang,?Xue-Yang Zhang,?Cheng-Long Shen,?Qing Lou,?Chong-Xin Shan

Abstract

In classical photodynamic therapy, tumor cells are killed by the cytotoxic species via type-I/II photochemical reactions, seriously limited by the external photoexcitation and hypoxia. Herein, the electron transfer mechanism between fluorophores and peroxalate-H2O2 reaction is investigated and the singlet/triplet electron exchange is utilized to achieve long-persistent chemiluminescence imaging and synergistic type-I/II/III photodynamic therapy. As a proof-of-concept, the photosensitizers of carbon nanodots (CDs)-loaded chlorin e6 (CDs-Ce6) are designed and integrated with the peroxalate molecules, and the as-prepare polymer carbon nanodots (p-CDs) exhibit novel tumor microenvironment (TME)-responsive long-persistent near-infrared CL and photochemical reactions, evoking the in vivo imaging and synergistic dynamic therapy in tumor tissue. Mechanistically, the excess reactive oxygen species in TME can trigger the chemically initiated singlet/triplet electron exchange between the hydrophobic CDs-Ce6 and peroxalate-derived 1,2-dioxetanes and thus the excess excited singlet/triplet electron of the CDs-Ce6 can ensure the long-persistent near-infrared CL, type I/II photochemical production of hydroxyl radicals, superoxide radical and singlet oxygen, and type III photochemical damage of maladjusted biomacromolecules, enabling the long-persistent near-infrared biological imaging and enhanced cancer therapy. These results shed a new sight into the energy transfer mechanism in chemiluminescence and pave a new sight into the architecture of multifunctional theragnostic nanoplatforms.

Substances (5)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Citric acid 77-92-9 C6H8O7 2073 suppliers $5.00-$2290.00
N,N-Dimethylformamide 68-12-2 C3H7NO 1313 suppliers $11.20-$12200.00
Urea 57-13-6 CH4N2O 1047 suppliers $5.00-$9960.00
Ethanol 64-17-5 C2H6O 955 suppliers $10.00-$28350.00
Polyethylene-polypropylene glycol 9003-11-6 (C3H6O.C2H4O)x 794 suppliers $20.00-$17325.00

Similar articles

IF:7.7

Fe-coordinated carbon dots with single atom nanozyme catalytic activity for synergistic catalytic/chemo-therapy in breast cancer

International Journal of Biological Macromolecules Mengke Lu, Jianxia Ding,etc Published: 1 December 2024
IF:16.6

Adenosine 5'-monophosphate in asthma: gas exchange and sputum cellular responses.

European Respiratory Journal H A Manrique, F P Gómez,etc Published: 1 June 2008
万全县| 荣昌县| 新泰市| 客服| 镇雄县| 平遥县| 泸西县| 西乌珠穆沁旗| 临泉县| 当雄县| 绩溪县| 田林县| 岳普湖县| 紫金县| 苍梧县| 马龙县| 酉阳| 长宁区| 图们市| 东乡县| 江西省| 揭西县| 丰顺县| 常熟市| 宁城县| 阜南县| 吉木乃县| 合川市| 西丰县| 旬阳县| 兴国县| 武山县| 陆丰市| 都兰县| 铁岭县| 怀宁县| 黄龙县| 阿拉尔市| 凤翔县| 淮滨县| 兴国县|