一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> ACS Applied Materials & Interfaces >>article
ACS Applied Materials & Interfaces

ACS Applied Materials & Interfaces

IF: 8.3
Download PDF

Dissolving PEGDA-Based Microneedles to Transdermally Deliver PDA@ Cu with Photothermal Properties for Potential Antibacterial Applications

Published:12 December 2024 DOI: 10.1021/acsami.4c17271 PMID: 39668550
Ya Gao,?Haoping Huo,?Renyuan Zhang,?Haonan Gao,?Yancheng Liu,?Yingbo Wang

Abstract

The stratum corneum of the skin functions as a barrier, obstructing drug absorption and complicating the treatment of skin infections caused by pathogens such as bacteria, fungi, and viruses through topical methods. In this research, a microneedle patch was developed, which consists of gelatin-sucrose (SG) that encapsulates polydopamine-copper nanoparticles (PDA@Cu) at the tip for antibacterial purposes. Poly(ethylene glycol) diacrylate (PEGDA) served as the primary substrate for the microneedle shaft (PDA@Cu-SG/PEGDA). This patch was engineered to enhance skin permeability and facilitate the efficient delivery of drugs through the rapid dissolution of the tips. Coordinate bonds can be formed between PDA and Cu ions, resulting in the immobilization of Cu particles on the PDA surface, which aids in the green synthesis of PDA@Cu photothermal antibacterial particles. The SG polymer, which contained PDA@Cu, was employed to fill the tip cavities through a series of centrifugation steps. Subsequently, UV-induced polymerization was carried out to produce PEGDA microneedles with hydrophilic tips (PDA@Cu-SG/PEGDA). Furthermore, the physicochemical characteristics of the polymer microneedles, including morphology, composition, and mechanical strength, were thoroughly characterized. These microneedles with hydrophilic tips demonstrated sufficient mechanical strength. Owing to the ability of PDA@Cu to disrupt bacterial membranes, the microneedle patch demonstrated excellent in vitro antibacterial efficacy. We validated the antibacterial activity of the microneedle patch against Escherichia coli and Staphylococcus aureus by conducting in vitro bacterial plate coating assays. The results of the assays indicated that this minimally invasive strategy achieved broad-spectrum antibacterial effects; thus, this may be a suitable approach for managing polymicrobial skin infections during clinical trials.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Sodium hydroxide 1310-73-2 NaOH 1358 suppliers $14.00-$17490.00
Agarose 9012-36-6 C10H15N3O3 730 suppliers $18.53-$3090.00
3-Hydroxytyramine 51-61-6 C8H11NO2 200 suppliers Inquiry
FETUIN 9014-81-7 NULL 92 suppliers $37.07-$4810.00

Similar articles

IF:10.7

Antibacterial betaine modified chitosan-based hydrogel with angiogenic property for photothermal enhanced diabetic wound repairing

Carbohydrate Polymers Kaiyue Zhang, Jingjing Zhu,etc Published: 19 November 2024
IF:4.9

Naringin: Nanotechnological Strategies for Potential Pharmaceutical Applications.

Pharmaceutics Soledad Ravetti, Ariel G Garro,etc Published: 7 March 2023
IF:5.3

Food fortification strategies to deliver nutrients for the management of iron deficiency anaemia.

ACS Applied Nano Materials Naman Kaur, Aparna Agarwal,etc Published: 23 October 2022
万源市| 清丰县| 阆中市| 罗城| 承德县| 隆尧县| 花垣县| 准格尔旗| 城固县| 定陶县| 无极县| 江都市| 永仁县| 中西区| 凌海市| 博兴县| 惠东县| 凭祥市| 日喀则市| 万年县| 瑞丽市| 定兴县| 靖州| 鱼台县| 南召县| 乐至县| 广丰县| 德惠市| 和田县| 施甸县| 潮安县| 牙克石市| 普兰店市| 米泉市| 花垣县| 新民市| 温宿县| 新泰市| 田林县| 武清区| 新丰县|