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International Journal of Pharmaceutics

International Journal of Pharmaceutics

IF: 5.3
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Bromocriptine mesylate-loaded nanoparticles co-modified with low molecular weight protamine and lactoferrin for enhanced nose-to-brain delivery in Parkinson's?…

Published:10 December 2024 DOI: 10.1016/j.ijpharm.2024.125054 PMID: 39667592
Huijing Cong,?Jing Hu,?Jing Wang,?Baiyu Chang,?Rongtao Li,?Xinran Cui,?Chenghao Zhang,?Hongyu Ji,?Congcong Lin,?Jingling Tang,?Jiaxin Liu

Abstract

Parkinson's disease confronts challenges in drug delivery due to the blood-brain barrier. Intranasal delivery bypasses the blood-brain barrier for improved drug bioavailability, yet narrow nasal space and brief retention time hinder clinical applicability. We conducted a Bromocriptine Mesylate-loaded PLGA nanoparticles co-modified with low molecular weight protamine (LMWP) and lactoferrin (Lf) (LMWP/Lf-BCM-NPs) for nose-to-brain delivery. The resulting LMWP/Lf-BCM-NPs were uniform spheres with an average size of 248.53?±?16.25?nm and zeta potential of -2.63?±?0.74?mV. Fourier transform infrared spectroscopy confirmed LMWP and Lf attachment. The co-modified nanoparticles showed improving cellular transport and good viability. The LMWP/Lf-BCM-NPs showed increased brain targeting efficiency in mice. In haloperidol-induced Parkinson mouse models, the LMWP/Lf-BCM-NPs showed increased brain targeting efficiency, enhanced behavioral regulatory effects, enhanced antioxidant effects and neuroprotection effects. This study paves the way for a novel, non-invasive brain-targeted therapy, offering a promising avenue for Parkinson's disease clinical treatment.

Substances (3)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Sodium deoxycholate 302-95-4 C24H41NaO4 680 suppliers $5.00-$11580.00
Haloperidol 52-86-8 C21H23ClFNO2 435 suppliers $30.00-$1504.50
MTT 2348-71-2 C18H16BrN5S 49 suppliers Inquiry

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