一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> International Journal of Pharmaceutics >>article
International Journal of Pharmaceutics

International Journal of Pharmaceutics

IF: 5.3
Download PDF

Bromocriptine mesylate-loaded nanoparticles co-modified with low molecular weight protamine and lactoferrin for enhanced nose-to-brain delivery in Parkinson's?…

Published:10 December 2024 DOI: 10.1016/j.ijpharm.2024.125054 PMID: 39667592
Huijing Cong,?Jing Hu,?Jing Wang,?Baiyu Chang,?Rongtao Li,?Xinran Cui,?Chenghao Zhang,?Hongyu Ji,?Congcong Lin,?Jingling Tang,?Jiaxin Liu

Abstract

Parkinson's disease confronts challenges in drug delivery due to the blood-brain barrier. Intranasal delivery bypasses the blood-brain barrier for improved drug bioavailability, yet narrow nasal space and brief retention time hinder clinical applicability. We conducted a Bromocriptine Mesylate-loaded PLGA nanoparticles co-modified with low molecular weight protamine (LMWP) and lactoferrin (Lf) (LMWP/Lf-BCM-NPs) for nose-to-brain delivery. The resulting LMWP/Lf-BCM-NPs were uniform spheres with an average size of 248.53?±?16.25?nm and zeta potential of -2.63?±?0.74?mV. Fourier transform infrared spectroscopy confirmed LMWP and Lf attachment. The co-modified nanoparticles showed improving cellular transport and good viability. The LMWP/Lf-BCM-NPs showed increased brain targeting efficiency in mice. In haloperidol-induced Parkinson mouse models, the LMWP/Lf-BCM-NPs showed increased brain targeting efficiency, enhanced behavioral regulatory effects, enhanced antioxidant effects and neuroprotection effects. This study paves the way for a novel, non-invasive brain-targeted therapy, offering a promising avenue for Parkinson's disease clinical treatment.

Substances (3)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Sodium deoxycholate 302-95-4 C24H41NaO4 680 suppliers $5.00-$11580.00
Haloperidol 52-86-8 C21H23ClFNO2 435 suppliers $30.00-$1504.50
MTT 2348-71-2 C18H16BrN5S 49 suppliers Inquiry

Similar articles

IF:10.7

Antibacterial betaine modified chitosan-based hydrogel with angiogenic property for photothermal enhanced diabetic wound repairing

Carbohydrate Polymers Kaiyue Zhang, Jingjing Zhu,etc Published: 19 November 2024
IF:5.3

Preparation and characterization of Tamoxifen citrate loaded nanoparticles for breast cancer therapy.

ACS Applied Nano Materials Ruma Maji, Niladri Shekhar Dey,etc Published: 25 June 2014
吉安县| 莱芜市| 尼玛县| 积石山| 滕州市| 绥化市| 双桥区| 铜梁县| 扶沟县| 丰镇市| 赤壁市| 卢龙县| 佛山市| 海晏县| 平阴县| 手机| 天等县| 大余县| 广州市| 舒兰市| 鄱阳县| 和顺县| 南京市| 广西| 淮北市| 梓潼县| 古蔺县| 甘孜县| 兴义市| 安陆市| 十堰市| 遂平县| 台州市| 宜城市| 娱乐| 忻城县| 辉县市| 廊坊市| 荔浦县| 大城县| 博爱县|