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Cell host & microbe

Cell host & microbe

IF: 18.7
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Roseburia intestinalis-derived butyrate alleviates neuropathic pain

Published:19 December 2024 DOI: 10.1016/j.chom.2024.11.013
Yanjun Jiang, Ziheng Huang, Wuping Sun, Jiabin Huang, Yunlong Xu, Yuliang Liao, Tingting Jin, Qing Li, Idy Hiu Ting Ho, Yidan Zou, Wenyi Zhu, Qian Li, Fenfen Qin, Xinyi Zhang, Shuqi Shi, Na Zhang, Shaomin Yang, Wenhui Xie, Songbin Wu, Likai Tan, Xiaodong Liu

Abstract

Approximately 20% of patients with shingles develop postherpetic neuralgia (PHN). We investigated the role of gut microbiota in shingle- and PHN-related pain. Patients with shingles or PHN exhibited significant alterations in their gut microbiota with microbial markers predicting PHN development among patients with shingles. Functionally, fecal microbiota transplantation from patients with PHN to mice heightened pain sensitivity. Administration of Roseburia intestinalis, a bacterium both depleted in patients with shingles and PHN, alleviated peripheral nerve injury-induced pain in mice. R.?intestinalis enhanced vagal neurotransmission to the nucleus tractus solitarius (NTS) to suppress the central amygdala (CeA), a brain region involved in pain perception. R.?intestinalis-generated butyrate activated vagal neurons through the receptor, G protein-coupled receptor 41 (GPR41). Vagal knockout of Gpr41 abolished the effects of R.?intestinalis on the NTS-CeA circuit and reduced pain behaviors. Overall, we established a microbiota-based model for PHN risk assessment and identified R.?intestinalis as a potential pain-alleviating probiotic.

Substances (20)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Metronidazole 443-48-1 C6H9N3O3 944 suppliers $13.00-$2650.00
Metronidazole 443-48-1 C6H9N3O3 944 suppliers $13.00-$2650.00
Metronidazole 443-48-1 C6H9N3O3 944 suppliers $13.00-$2650.00
Metronidazole 443-48-1 C6H9N3O3 944 suppliers $13.00-$2650.00
Neomycin sulfate 1405-10-3 C23H48N6O17S 903 suppliers $5.00-$3884.60
Neomycin sulfate 1405-10-3 C23H48N6O17S 903 suppliers $5.00-$3884.60
Neomycin sulfate 1405-10-3 C23H48N6O17S 903 suppliers $5.00-$3884.60
Neomycin sulfate 1405-10-3 C23H48N6O17S 903 suppliers $5.00-$3884.60
Vancomycin hydrochloride 1404-93-9 C66H76Cl3N9O24 746 suppliers $7.00-$6850.00
Vancomycin hydrochloride 1404-93-9 C66H76Cl3N9O24 746 suppliers $7.00-$6850.00
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