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ChemicalBook >> journal list >> Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy >>article

Engineered DR/NIR dual-emission carbonized polymer dots for simultaneous tracking of lipid droplets and lysosomes

Published:17 December 2024 DOI: 10.1016/j.saa.2024.125598 PMID: 39706069
Shan Miao , Junyong Sun , Ying Li , Qiang Zhang , Hongqi Chen , Feng Gao

Abstract

Developing near-infrared fluorescent probes for simultaneous tracking of lipid droplets (LDs) and lysosomes is highly desirable for studying cell metabolism. In this work, deep-red/near-infrared dual-emission carbonized polymer dots (DN-CPDs) were prepared for ratiometric monitoring of the intracellular polarity. Detailed structural analysis revealed that the deep-red emission and near-infrared peak of DN-CPDs originate from the molecular state and surface state, respectively. The surface-state emission was derived from the intraparticle charge-transfer (ICT) effect of the donor-bridge-acceptor (D-π-A) structure of DN-CPDs. The obtained DN-CPDs exhibited excellent dual-labeling ability, large Stokes shifts, ratiometric polarity sensitivity, high selectivity, and satisfactory photostability. Moreover, with the polarity distinction between LDs and lysosomes, DN-CPDs nanoprobes were successfully used to observe the dynamic changes of the two aforementioned organelles during starvation-induced lipophagy and drug-induced lipophagy inhibition processes. This work not only provides a useful tool for LD-lysosome related studies but is also valuable for the preparation of CPDs with long wavelength emission.

Substances (6)

Materials
Procduct Name CAS Molecular Formula Supplier Price
4,4-DIFLUORO-1,3,5,7,8-PENTAMETHYL-4-BORA-3A,4A-DIAZA-S-INDACENE 121207-31-6 C14H17BF2N2 168 suppliers $27.00-$1061.00
4,4-DIFLUORO-1,3,5,7,8-PENTAMETHYL-4-BORA-3A,4A-DIAZA-S-INDACENE 121207-31-6 C14H17BF2N2 168 suppliers $27.00-$1061.00
4,4-DIFLUORO-1,3,5,7,8-PENTAMETHYL-4-BORA-3A,4A-DIAZA-S-INDACENE 121207-31-6 C14H17BF2N2 168 suppliers $27.00-$1061.00
4,4-DIFLUORO-1,3,5,7,8-PENTAMETHYL-4-BORA-3A,4A-DIAZA-S-INDACENE 121207-31-6 C14H17BF2N2 168 suppliers $27.00-$1061.00
Pyrromethene 546 121207-31-6 - Inquiry
Pyrromethene 546 121207-31-6 - Inquiry

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