一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Journal of Clinical Investigation >>article
Journal of Clinical Investigation

Journal of Clinical Investigation

IF: 13.3
Download PDF

Tumor initiating cells escape tumor immunity via CCL8 from tumor-associated macrophages in mice

Published:7 January 2025 DOI: 10.1172/JCI180893 PMID: 39774471
Shuang Chen,?Chensong Huang,?Kang Li,?Maosheng Cheng,?Caihua Zhang,?Jianqi Xiong,?Guoli Tian,?Ruoxing Zhou,?Rongsong Ling,?Xiaochen Wang,?Gan Xiong,?Zhihui Zhang,?Jieyi Ma,?Yan Zhu,?Bin Zhou,?Liang Peng,?Zhenwei Peng,?Heping Li,?Demeng Chen

Abstract

Tumor-initiating cells (TICs) play a key role in cancer progression and immune escape. However, how TICs evade immune elimination remains poorly characterized. Combining single-cell RNA-Seq (scRNA-Seq), dual-recombinase-based lineage tracing, and other approaches, we identified a WNT-activated subpopulation of malignant cells that act as TICs in vivo. We found intensive reciprocal interactions between TICs and immune-regulatory tumor-associated macrophages (Reg-TAMs) via growth arrest-specific 6/AXL receptor tyrosine kinase/MER proto-oncogene, tyrosine kinase (GAS6/AXL/MERTK) signaling pathways, which facilitated the immune escape of TICs. In this study, we used chemical inhibitors and Axl/Mertk conditional double-KO (cDKO) mice to demonstrate that inhibiting the interaction between TIC-derived GAS6 and AXL/MERTK in Reg-TAMs reactivated antitumor immune responses. We identified CCL8 as a critical mediator of the GAS6/AXL/MERTK pathway, primarily by inhibiting Treg infiltration into the tumor. Furthermore, the AXL/MERTK signaling blockade sensitized tumor cells to anti-programmed cell death 1 (anti-PD-1) treatment. Thus, we elucidated a detailed mechanism by which TICs evade tumor immunity, providing insights into strategies to eradicate TICs that escape conventional immunotherapy.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
xav-939 284028-89-3 C14H11F3N2OS 239 suppliers $7.00-$3173.00
xav-939 284028-89-3 C14H11F3N2OS 239 suppliers $7.00-$3173.00
xav-939 284028-89-3 C14H11F3N2OS 239 suppliers $7.00-$3173.00
xav-939 284028-89-3 C14H11F3N2OS 239 suppliers $7.00-$3173.00

Similar articles

IF:6.9

Role of ginsenoside Rh2 in tumor therapy and tumor microenvironment immunomodulation

Biomedicine & Pharmacotherapy Sun Xiaodan , Cheng Ying,etc Published: 1 December 2022
IF:10.7

Label‐Free Prediction of Tumor Metastatic Potential via Ramanome

Small Methods Yuxing Zhang, Yanmei Zhang,etc Published: 19 November 2024
封开县| 汾西县| 哈尔滨市| 南澳县| 广西| 莫力| 桐柏县| 开鲁县| 五台县| 台江县| 肇源县| 凤冈县| 祁连县| 沈阳市| 仙桃市| 昔阳县| 禹州市| 宁阳县| 百色市| 同德县| 安徽省| 玉环县| 龙南县| 昌邑市| 当涂县| 孝昌县| 巩义市| 延寿县| 张掖市| 六枝特区| 雅安市| 揭阳市| 黎川县| 鞍山市| 札达县| 大田县| 和田县| 扶余县| 廉江市| 浦城县| 田林县|