一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Journal of Nanobiotechnology >>article
Journal of Nanobiotechnology

Journal of Nanobiotechnology

IF: 10.6
Download PDF

Delivery of FGF18 using mRNA-LNP protects the cartilage against degeneration via alleviating chondrocyte senescence

Published:22 January 2025 DOI: 10.1186/s12951-025-03103-9 PMID: 39844298
Keyu Kong,?Baixing Li,?Yongyun Chang,?Chen Zhao,?Hua Qiao,?Minghao Jin,?Xinru Wu,?Wenxuan Fan,?Liao Wang,?Yansong Qi,?Yongsheng Xu,?Zanjing Zhai,?Peixiang Ma,?Huiwu Li

Abstract

Background: Osteoarthritis (OA) is a degenerative joint disease with an immense unmet medical need. FGF18 protein is a potential regenerative factor for cartilage repair. However, traditional protein delivery methods have limited efficacy due to the short lifetime and shallow infiltration.

Results: In this work, we discovered that lipid nanoparticle (LNP) can infiltrate and deliver FGF18 mRNA deeper in the cartilage than proteins. After mRNA UTR optimization and chemical modification, the expression of FGF18 can last up to 6 days in the cartilage. Furthermore, delivering FGF18 mRNA activates FOXO3a-autophagy pathway, which protects against chondrocyte degeneration and senescence. Local intra-articular injection of FGF18 mRNA-LNP significantly alleviates OA symptoms in DMM and senile OA models. Sustained expression and accessibility of FGF18-mRNA to deeper chondrocytes makes LNP-mRNA more effective than FGF18 recombinant protein.

Conclusions: In summary, this study presents a novel approach superior to recombinant protein alone and holds promise as a new therapeutic strategy for OA.

Substances (6)

Materials
Procduct Name CAS Molecular Formula Supplier Price
3-METHYLADENINE 5142-23-4 C6H7N5 397 suppliers $12.00-$4500.00
3-METHYLADENINE 5142-23-4 C6H7N5 397 suppliers $12.00-$4500.00
3-METHYLADENINE 5142-23-4 C6H7N5 397 suppliers $12.00-$4500.00
3-METHYLADENINE 5142-23-4 C6H7N5 397 suppliers $12.00-$4500.00
3H-?Purin-?6-?amine, 3-?methyl- 5142-23-4 C6H7N5 - Inquiry
3H-?Purin-?6-?amine, 3-?methyl- 5142-23-4 C6H7N5 - Inquiry

Similar articles

IF:5.4

Determination of 2-Acetyl-1-pyrroline via a Color-Change Reaction Using Chromium Hexacarbonyl.

ACS Applied Energy Materials Chonlada Bennett, Woraprapa Sriyotai,etc Published: 20 June 2022
高州市| 电白县| 沧源| 肥乡县| 东山县| 米林县| 资阳市| 沙河市| 岳西县| 武夷山市| 夏邑县| 建阳市| 镇原县| 西乡县| 平塘县| 佛冈县| 祁东县| 丹寨县| 宜州市| 上栗县| 巴林左旗| 宜春市| 鄂托克旗| 阿拉善右旗| 昌图县| 宜宾市| 固阳县| 英山县| 灵武市| 边坝县| 六枝特区| 察雅县| 河北省| 客服| 巴里| 巫溪县| 民勤县| 邢台市| 台中县| 桓台县| 青铜峡市|