一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Biomedicine & Pharmacotherapy >>article
Biomedicine & Pharmacotherapy

Biomedicine & Pharmacotherapy

IF: 6.9
Download PDF

A novel missense mutation Smad4 V354L enhances the efficacy of docetaxel in non-small cell lung cancer.

Published:8 February 2025 DOI: 10.1016/j.biopha.2025.117899
Xia Xue , Yongjia Zhou , Huiping Liu , Yan Gao , Xinyu Ma , Zhaohua Xiao , Wenhao Zhang , Peichao Li , Zhongxian Tian , Yun Luan , Xiaogang Zhao

Abstract

NSCLC is?a heterogeneous disease with unique combinations of somatic molecular alterations in individual patients. The different mutations in tumor oncogene and suppressors might be associated with the response to therapy. However, little is known about how Smad4 genomic alterations cause the therapeutic effect of docetaxel. The retrospective analysis was conducted on 49 patients with stage IIB or IIIA non-small cell lung cancer receiving docetaxel chemotherapy. One novel missense variant, c.1060 G >?C in Smad4 was identified by next-generation sequencing. The Smad4c.1060?G >?C variant results in the substitution of valine with leucine at amino acid 354 (p.Val354Leu, V354L). The clinical analysis showed that the patients with Smad4 V354L mutation receiving docetaxel treatment manifested better prognosis with prolonged disease-free survival and overall survival compared with patients with the wild-type. Smad4 V354L cells demonstrated increased sensitivity to docetaxel with apoptosis and G2/M cell cycle arrest. Furthermore, the cell-cycle related protein expression of CDK2 was remarkably decreased, while the expression of cyclin-dependent kinase inhibitor p21 Waf1 and p27 Kip1 was significantly increased. In vivo experiments further demonstrated the increased inhibitory effects of docetaxel in the nude mice inoculated with Smad4 V354L cells compared to the mice inoculated with wild-type cells group. The novel V354L missense mutation of Smad4 gene enhances the efficacy of docetaxel in non-small cell lung cancer, which would provide new opportunities for precise clinical therapy of NSCLC.

Similar articles

IF:9.6

EGFR exon 20 insertions in advanced non-small cell lung cancer: A new history begins

Cancer treatment reviews Jordi Remon , Lizza E.L. Hendriks ,etc Published: 1 November 2020
IF:3

A comprehensive review on Brigatinib – A wonder drug for targeted cancer therapy in non-small cell lung cancer

Saudi Pharmaceutical Journal Silky Bedi , Shah A. Khan ,etc Published: 1 September 2018
黎城县| 台中县| 集安市| 吴旗县| 台东县| 天等县| 富裕县| 金湖县| 临夏县| 沅陵县| 二连浩特市| 天等县| 盘山县| 夏邑县| 吉木乃县| 光山县| 尉犁县| 达拉特旗| 胶南市| 隆尧县| 乳源| 宜春市| 饶平县| 石屏县| 迭部县| 阳江市| 平远县| 绥化市| 阿勒泰市| 永平县| 新乡市| 凉城县| 儋州市| 突泉县| 西平县| 临夏县| 庄河市| 松溪县| 凤庆县| 阿克| 政和县|