一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Advanced Science >>article
Advanced Science

Advanced Science

IF: 14.3
Download PDF

Carnosic Acid Directly Targets STING C-Terminal Tail to Improve STING-Mediated Inflammatory Diseases

Published:18 February 2025 DOI: 10.1002/advs.202417686 PMID: 39965124
Wenqing Mu, Guang Xu, Ling Li, Jincai Wen, Ye Xiu, Jia Zhao, Tingting Liu, Ziying Wei, Wei Luo, Huijie Yang, Zhixin Wu, Xiaoyan Zhan, Xiaohe Xiao, Zhaofang Bai

Abstract

cGAS (cyclic GMP-AMP synthase)-STING (stimulator of interferon genes) signaling plays a vital role in innate immunity, while its deregulation may lead to a wide variety of autoinflammatory and autoimmune diseases. It is essential to identify specifically effective lead compounds to inhibit the signaling. Herein, it is shown that carnosic acid (CA), an active ingredient of medicinal plant Rosmarinus officinalis L., specifically suppressed cGAS-STING pathway activation and the subsequent inflammatory responses. Mechanistically, CA directly bound to STING C-terminal tail (CTT), impeded the recruitment of TANK-binding kinase 1 (TBK1) onto STING signalosome, thereby blocking the phosphorylation of STING and interferon regulatory factor 3 (IRF3) nuclear translocation. Importantly, CA dramatically attenuated STING-mediated inflammatory responses in vivo. Consistently, CA has a salient ameliorative effect on autoinflammatory disease model mediated by Trex1 deficiency, via inhibition of the cGAS-STING signaling. Notably, the study further indicates that phenolic hydroxyl groups are essential for CA-mediated STING inhibitory activity. Collectively, the results thus identify STING as one of the crucial targets of CA for mediating CA's anti-inflammatory activity, and further reveal that STING CTT may be a novel promising target for drug development.

Substances (12)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Carnosic acid 3650-09-7 C20H28O4 445 suppliers $8.00-$1010.00
Carnosic acid 3650-09-7 C20H28O4 445 suppliers $8.00-$1010.00
Carnosic acid 3650-09-7 C20H28O4 445 suppliers $8.00-$1010.00
Carnosic acid 3650-09-7 C20H28O4 445 suppliers $8.00-$1010.00
CARNOSOL 5957-80-2 C20H26O4 256 suppliers $17.00-$1528.00
CARNOSOL 5957-80-2 C20H26O4 256 suppliers $17.00-$1528.00
CARNOSOL 5957-80-2 C20H26O4 256 suppliers $17.00-$1528.00
CARNOSOL 5957-80-2 C20H26O4 256 suppliers $17.00-$1528.00
Rosmanol 80225-53-2 C20H26O5 134 suppliers $60.00-$1794.00
Rosmanol 80225-53-2 C20H26O5 134 suppliers $60.00-$1794.00

Similar articles

IF:14.3

A Purely Biomanufactured System for Delivering Nanoparticles and STING Agonists

Advanced Science Yu‐an Li, Yi Feng,etc Published: 26 November 2024
IF:4.3

The Pharmacological Effect of Hemin in Inflammatory-Related Diseases: A Systematic Review

ACS Applied Electronic Materials Jo?o Estarreja, Gon?alo Caldeira,etc Published: 18 April 2024
IF:5.3

Suppressive effects of methylthiouracil on polyphosphate-mediated vascular inflammatory responses

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Gahee Min, Sae-Kwang Ku,etc Published: 15 July 2016
含山县| 高青县| 赤峰市| 肥西县| 仙居县| 教育| 农安县| 仪陇县| 遂昌县| 盐边县| 吴忠市| 孟津县| 德庆县| 安宁市| 山阴县| 绥芬河市| 佛冈县| 台东县| 德令哈市| 交口县| 镇宁| 瑞丽市| 玛沁县| 清镇市| 云龙县| 丹寨县| 邵武市| 满洲里市| 青岛市| 湖口县| 磴口县| 新乐市| 蒙自县| 昭觉县| 黄冈市| 时尚| 林周县| 阿拉善右旗| 昌图县| 堆龙德庆县| 巩义市|