一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Cell >>article
Cell

Cell

IF: 45.5
Download PDF

Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response

Published:28 February 2025 DOI: 10.1016/j.cell.2025.01.043
Xiadi He, Qiwei Wang, Xin Cheng, Weihua Wang, Yutong Li, Yabing Nan, Jiang Wu, Bingqiu Xiu, Tao Jiang, Johann S. Bergholz, Hao Gu, Fuhui Chen, Guangjian Fan, Lianhui Sun, Shaozhen Xie, Junjie Zou, Sheng Lin, Yun Wei, James Lee, John M. Asara, Jean J. Zhao

Abstract

Vitamin C (vitC) is essential for health and shows promise in treating diseases like cancer, yet its mechanisms remain elusive. Here, we report that vitC directly modifies lysine residues to form “vitcyl-lysine”—a process termed vitcylation. Vitcylation occurs in a dose-, pH-, and sequence-dependent manner in both cell-free systems and living cells. Mechanistically, vitC vitcylates signal transducer and activator of transcription-1 (STAT1)- lysine-298 (K298), impairing its interaction with T?cell protein-tyrosine phosphatase (TCPTP) and preventing STAT1-Y701 dephosphorylation. This leads to enhanced STAT1-mediated interferon (IFN) signaling in tumor cells, increased major histocompatibility complex (MHC)/human leukocyte antigen (HLA) class I expression, and activation of anti-tumor immunity in?vitro and in?vivo. The discovery of vitcylation as a distinctive post-translational modification provides significant insights into vitC’s cellular function and therapeutic potential, opening avenues for understanding its biological effects and applications in disease treatment.

Substances (16)

Materials
Procduct Name CAS Molecular Formula Supplier Price
STAUROSPORINE 62996-74-1 C28H26N4O3 451 suppliers $10.00-$3200.00
STAUROSPORINE 62996-74-1 C28H26N4O3 451 suppliers $10.00-$3200.00
STAUROSPORINE 62996-74-1 C28H26N4O3 451 suppliers $10.00-$3200.00
STAUROSPORINE 62996-74-1 C28H26N4O3 451 suppliers $10.00-$3200.00
IOX2 931398-72-0 C19H16N2O5 150 suppliers $9.00-$1654.10
IOX2 931398-72-0 C19H16N2O5 150 suppliers $9.00-$1654.10
IOX2 931398-72-0 C19H16N2O5 150 suppliers $9.00-$1654.10
IOX2 931398-72-0 C19H16N2O5 150 suppliers $9.00-$1654.10
Bobcat339 (Bobcat 339) 2280037-51-4 C16H12ClN3O 52 suppliers Inquiry
Bobcat339 (Bobcat 339) 2280037-51-4 C16H12ClN3O 52 suppliers Inquiry

Similar articles

IF:4.2

C-type lectin 9 participates in the immune response, development and reproduction of Tribolium castaneum

Pesticide Biochemistry and Physiology Chengjun Li, Huayi Ai,etc Published: 27 November 2024
IF:0

Gestational diabetes mellitus is associated with a low serum level of mitochondrial-derived peptide-MOTS-C

Turk biyokimya dergisi = Turkish journal of biochemistry Serdar ?zer, Filiz Alkan Baylan,etc Published: 21 September 2023
IF:5.4

Dietary Intake of Vitamin B12 is Better for Restoring a Low B12 Status Than a Daily High-Dose Vitamin Pill: An Experimental Study in Rats.

ACS Applied Energy Materials Eva Greibe, Ole Nymark,etc Published: 15 August 2018
莱西市| 台南县| 西城区| 徐闻县| 彩票| 斗六市| 正安县| 洛扎县| 秦安县| 洪雅县| 武义县| 河西区| 香格里拉县| 武穴市| 白山市| 石首市| 四子王旗| 荣昌县| 龙井市| 梧州市| 玛曲县| 余姚市| 湘潭市| 长武县| 镇赉县| 丹东市| 东海县| 哈尔滨市| 郁南县| 当阳市| 清苑县| 威宁| 同仁县| 新源县| 昌宁县| 驻马店市| 汝州市| 阿拉善右旗| 昂仁县| 上饶县| 昌吉市|