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Neuroscience bulletin

Neuroscience bulletin

IF: 5.9
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A Novel Functional Method of Protector Screening for Zebrafish Lateral Line Hair Cells via the Acoustic Escape Response

Published:1 September 2025 DOI: 10.1007/s12264-025-01406-3 PMID: 40329138
Ling Zheng,?Qiaosen Shen,?Tong Zhao,?Qingsong Liu,?Zihao Huang,?Feng Zhao,?Mengqian Zhang,?Yongdong Song,?Daogong Zhang,?Dong Liu,?Fangyi Chen

Abstract

Zebrafish larvae are useful for identifying chemicals against lateral line (LL) hair cell (HC) damage and this type of chemical screen mainly focuses on searching for protectors against cell death. To expand the candidate pool of HC protectors, a self-built acoustic escape response (AER)-detecting system was developed to apply both low-frequency near-field sound transmission and AER image acquisition/processing modules. The device quickly confirmed the changed LL HC functions caused by most known ototoxins, protectors, and neural transmission modifiers, or knockdown of LL HC-expressing genes. With ten devices wired in tandem, five 'hit' chemicals were identified from 124 cyclin-dependent kinase inhibitors to partially restore cisplatin-damaged AER in less than a day. AS2863619, ribociclib, and SU9516 among the hits, protected the HCs in the mouse cochlea. Therefore, using free-swimming larval zebrafish, the self-made AER-detecting device can efficiently identify compounds that are protective against HC damage, including cell death and loss-of-function.

Substances (14)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Acetylcholine chloride 60-31-1 C7H16ClNO2 486 suppliers $5.00-$60400.00
Acetylcholine chloride 60-31-1 C7H16ClNO2 486 suppliers $5.00-$60400.00
Acetylcholine chloride 60-31-1 C7H16ClNO2 486 suppliers $5.00-$60400.00
Acetylcholine chloride 60-31-1 C7H16ClNO2 486 suppliers $5.00-$60400.00
Isradipine 75695-93-1 C19H21N3O5 303 suppliers $10.00-$1732.50
Isradipine 75695-93-1 C19H21N3O5 303 suppliers $10.00-$1732.50
Isradipine 75695-93-1 C19H21N3O5 303 suppliers $10.00-$1732.50
Isradipine 75695-93-1 C19H21N3O5 303 suppliers $10.00-$1732.50
10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE 122955-42-4 C26H20N2O 62 suppliers $48.00-$1600.00
10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE 122955-42-4 C26H20N2O 62 suppliers $48.00-$1600.00

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